Monitoring of Adverse Drug Reactions Caused by Hospital Preparations and Evaluation Systems

doi:10.19803/j.1672-8629.20250218

Abstract

Abstract: Objective To construct an intelligent adverse drug reaction (ADR) monitoring system for hospital-made preparations in order to prevent underreporting, data fragmentation, and delayed risk signals. Methods Based on Java 2 Platform and Enterprise Edition (J2EE), a multi-layer and distributed architecture system was designed to integrate the Hospital Information System (HIS) with the China Hospital Pharmacovigilance System (CHPS), making possible real-time synchronization and intelligent analysis of multi-source heterogeneous data. Its performance was evaluated through empirical studies conducted at two healthcare institutions in Yunnan and Guangdong. Results Among the 3,680 cases who had used blood-activating and stasis-resolving preparations, the identified incidence rate of ADR was 0.54 per thousand. In the 7,950 cases administered with heat-clearing and detoxifying preparations, one case of ADR was identified via active monitoring. Conclusion This system can quickly identify ADR risk signals associated with hospital preparations, but its performance needs to be verified by large-scale empirical studies.

Key words: Hospital Preparations, Adverse Drug Reactions, Monitoring, Pharmacovigilance, Intelligent Algorithms, Real-World Evidence

CLC Number:

R951
R994.11

JIANG Xiaofeng, YANG Shuting, BAI Liqin, QI Jun, HE Jianxiong, CHEN Wenge, LIANG Zuhong, LI Yu, YU Xiaoxia. Monitoring of Adverse Drug Reactions Caused by Hospital Preparations and Evaluation Systems[J]. Chinese Journal of Pharmacovigilance, 2025, 22(9): 1008-1011.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250218

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I9/1008

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