Chinese Journal of Pharmacovigilance ›› 2025, Vol. 22 ›› Issue (7): 823-825.
DOI: 10.19803/j.1672-8629.20240992

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One Case of Acute Generalized Exanthematous Pustulosis Caused by Abrocitinib Tablets

LI Min1, LI Chunlei2, SUN Cuicui2, YU Wenwen1, SUN Qing3, QI Yingmei1#, LIU Anchang2,*   

  1. 1Jinan Center for ADR and MDAE monitoring, Jinan Shandong 250102, China;
    2Department of Clinical Pharmacy, Qilu Hospital of Shandong University, Jinan Shandong 250021, China;
    3Department of Dermatology, Qilu Hospital of Shandong University, Jinan Shandong 250021, China
  • Received:2024-12-16 Online:2025-07-15 Published:2025-07-17

Abstract: Objective To analyze one case of acute generalized exanthematous pustulosis (AGEP) caused by abrocitinib tablets in order to provide a reference for rational clinical use and subsequent studies. Methods One rare case of AGEP in a patient with atopic dermatitis (AD) was reported after 3 days of medication with abrocitinib tablets 200 mg po qd, who had taken this drug for 15 days 100 mg qd. Related literature was reviewed. The causes and precautions were investigated. Results AGEP was possibly related to abrocitinib tablets, and such cases were very rare. The symptoms were relieved after effective treatment. Conclusion Clinicians need to be alert to AGEP caused by abrocitinib tablets. Quick detection and treatment are crucial.

Key words: Abrocitinib, Atopic Dermatitis (AD), Acute Generalized Exanthematous Pustulosis (AGEP), Adverse Drug Reaction(ADR), Case Report

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