Chinese Journal of Pharmacovigilance ›› 2025, Vol. 22 ›› Issue (7): 794-798.
DOI: 10.19803/j.1672-8629.20240988

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48 Cases of Hematological Adverse Reactions Associated with Piperacillin Sodium and Tazobactam Sodium

CHEN Yaozhe1, ZHAN Yunli2, SONG Xingdong1, ZHU Manyu2, OU Xuemei3, LI Chuyun1,*   

  1. 1Department of Pharmacy, Huizhou Central People’s Hospital, Huizhou Guangdong 516001, China;
    2Huizhou Adverse Drug Reaction Monitoring Center, Huizhou Guangdong 516001, China;
    3Department of Thoracic and Cardiac Surgery, Huizhou Central People’s Hospital, Huizhou Guangdong 516001, China
  • Received:2024-12-16 Online:2025-07-15 Published:2025-07-17

Abstract: Objective To investigate the adverse drug reactions (ADR) of piperacillin sodium and tazobactam sodium in the hematological system in order to provide a reference for rational medications. Methods Reports about hematological ADR caused by piperacillin sodium and tazobactam sodium submitted by a hospital in 2019-2023 were analyzed. Results Forty-eight related reports were collected, involving 36 males and 12 females with a mean age of (59.67±18.74) years. The hematological ADR were primarily manifested as thrombocytopenia (22 cases) and leukopenia (17 cases). The mean platelet count was (43.05±18.57)×109·L-1 for thrombocytopenia while the mean count of white blood cells was (1.71±0.83)×109·L-1 for leukopenia. The time to onset of ADR was (5.59±3.74) days and (21.14±6.04) days, respectively, with statistically significant differences (P<0.001). The symptoms included simultaneous reductions in white blood cells and platelets or in white blood cells, platelets and hemoglobin, and leukocytosis, thrombocytosis, and decreased hemoglobin levels. Clinically, most of the patients were asymptomatic, but a few had a fever. Following symptomatic treatment, 46 cases improved while 2 cases died. These ADR were mostly classified as grade III (25 cases). Among the patients with leukopenia, five were reexposed to piperacillin sodium and tazobactam sodium, and leukopenia recurred in one case. Conclusion The primary manifestations of hematological ADR induced by piperacillin sodium and tazobactam sodium include leukopenia and thrombocytopenia, which are clinically often asymptomatic or may present only with fever. Prompt discontinuation of medication and symptomatic treatment can lead to a favorable prognosis.

Key words: Piperacillin Sodium and Tazobactam Sodium, Hematologic Adverse Reactions, Leukopenia, Thrombocytopenia, Adverse Drug Reactions

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