Evaluation and Selection of Antitumor Activity of Sixteen Zhuang Toxic Medicinal Materials

doi:10.19803/j.1672-8629.20240392

Abstract

Abstract: Objective To study the anti-tumor activity of 16 toxic herbs of Zhuang medicine in order to provide references for the anti-tumor treatment with Zhuang medicine. Methods Based on the “poison theory” in Zhuang medicine, the tumor inhibitory effects of 16 medicinal materials were analyzed with literature research methods using toxic medicinal materials of Zhuang medicine collected from the national scientific resources investigation project. The results showed that these medicinal materials had inhibitory effects on tumors such as lung cancer, breast cancer, cervical cancer, and gastric cancer. Furthermore, the inhibitory effects and half inhibitory concentration (IC₅₀) of extracts of 16 kinds of toxic medicinal materials of Zhuang medicine on lung cancer A549 cells, breast cancer MCF-7cells, cervical cancer Hela cells and gastric cancer BGC823 cells were analyzed using the CCK-8 method. Results The extracts of RHIZOMA DYSOSMATIS had a significant inhibitory effects on the above four types of tumor cells with IC₅₀values of 0.928 6, 0.622 6, 0.240 5 and 1.737 mg·L^-1, respectively. The inhibitory effects were better than those of the positive control doxorubicin. The extracts of CROTONIS FRUCTUS had some inhibitory effects on the above four types of tumor cells, while the other 14 medicinal herbs had no inhibitory effect. Conclusion This research provide a reference for the development and application of anti-tumor effects of D. versipellis, and also provide a reference for the development of anti-tumor drugs derived from toxic medicinal materials.

Key words: Toxic Medicinal Materials, Extract, Antitumor, RHIZOMA DYSOSMATIS, Zhuang Medicine, Doxorubicin

CLC Number:

R994.11
R285

SONG Zhongxu, HU Jiaojiao, JIN Yan, ZHAO Yuyang, TIAN Hui, YUAN Yuan. Evaluation and Selection of Antitumor Activity of Sixteen Zhuang Toxic Medicinal Materials[J]. Chinese Journal of Pharmacovigilance, 2025, 22(5): 539-546.

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https://zgywjj.magtechjournal.com/EN/Y2025/V22/I5/539

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