Abstract: Objective To find out more about the disease mechanism of ischemic stroke, evaluate the therapeutic efficacy and predict prognosis. Methods The latest progress in clinical models, pharmacological models (including in vivo and in vitro models), and other emerging models related to ischemic stroke research was summarized. Results Clinical models were mostly used for risk prediction, prognosis assessment, and treatment decision support. Pharmacological models played a crucial role in mechanism exploration and drug screening. Emerging computer models and multi-omics models offered new perspectives for personalized treatments and precision medicine. Conclusion Despite significant advancements in ischemic stroke research, these models are still facing challenges related to clinical relevance, model integration, and translational applications. Future research should try to work on the accuracy and generalizability of models, strengthen multidisciplinary collaboration, and promote the translation of basic research into clinical practices in order to improve diagnosis, treatments, and quality of life for patients with ischemic stroke.

Key words: Ischemic Stroke, Clinical Models, Pharmacological Models, In Vivo Models, In Vitro Models, Computer Models