Risk Analysis and Mechanism Discussion of Cardiovascular, Hepatic, or Nephrotoxicity Induced by Tripterygium Wilfordii

doi:10.19803/j.1672-8629.20240498

Abstract

Abstract: Objective To analyze the characteristics and potential mechanisms of adverse drug reactions/events (ADR/ADE) in the heart, liver, or kidney caused by Tripterygium wilfordii (Leigongteng), with the aim of providing reference for the rational use of medicine in clinical practice. Methods The ADR/ADE in the heart, liver, or kidneys caused by Leigongteng were collected retrospectively from the China National Knowledge Infrastructure (CNKI) from constrac tion to 1, Jan 2024. By using Apriori association analysis and decision tree CART algorithm, the influencing factors that caused by Leigonteng to the heart, liver, or kidneys damage were conducted. After collectting the compounds contained in Leigongteng and the action targets of the heart, liver, or kidneys based on the Traditional Chinese Medicine Systems Pharmacology Analysis Platform and GeneCards database, using network pharmacology to analyze the intrinsic mechanisms of Leigongteng’s multi-organ toxicity. Results A total of 50 cases ADR/ADE involved the heart, liver, or kidneys damage were collected, among which 20 cases involved two or more systems-organs. There was a strong correlation between the toxicity to the heart, liver, or kidneys and the dosage and duration of medication, and there was also a certain association with the patient’s original diseases. 51 compounds from Leigongteng and 153 effective action targets were screened out. Through the use of Venn diagrams, 987 common targets of toxicity to the heart, liver, and kidneys were identified. Protein-protein interaction network and Gene Ontology functional analysis revealed that TP53-mediated apoptosis, AKT1 and STAT3-mediated inflammatory responses may be associated with the multi-organ toxicity of Leigongteng to the heart, liver, and kidneys. Conclusion The multi-organ toxicity caused by Leigongteng has intrinsic correlations that require further in-depth research, and clinical prevention necessitates strict control over the dosage and duration of medication use.

Key words: Tripterygium Wilfordii, Heart, Liver, Kidney, Risk Analysis, Risk Mechanism, Pharmacovigilance

CLC Number:

R994.11

CHEN Lijuan, ZHANG Xiaomeng, GAO Fujun, LIU Zeyu, WANG Yu, ZHANG Bing. Risk Analysis and Mechanism Discussion of Cardiovascular, Hepatic, or Nephrotoxicity Induced by Tripterygium Wilfordii[J]. Chinese Journal of Pharmacovigilance, 2024, 21(11): 1224-1231.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240498

https://zgywjj.magtechjournal.com/EN/Y2024/V21/I11/1224

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