Abstract: Objective To provide reference for rational medication of psoriasis by analyzing the demographic and drug characteristics of drug-induced liver injury for psoriasis treatment. Methods A retrospective study was performed in drug-induced liver injury cases associated with psoriasis between January 2012 and December 2016. Results A total of 155 DILI cases were collected, including 101 males and 54 females. The age range is 11 to 80 years and the age of 31~50 accounted for 48.38%. 120 cases(77.42%) of patients had clear history of medication, DILI caused by the traditional Chinese medicines(TCM) accounted for 32.5%, and DILI caused by western medicines accounted for 67.5%. The time span from taking drugs until liver injury occurred concentrated in 30 days. The median time of TCM (16 days) was longer than that of western medicines (10.5 days). Primary suspected western medicines were acitretin (38.27%) and methotrexate (34.57%). Suspected TCM mainly included tripterygium glycosides tablet(28.30%), Keyin pill(23.07%) and compound Qingdai capsule(15.38%). 35 cases (22.58%) of patients took two or more drugs, and the significant difference existed in the severity of adverse reactions caused by combined and single medication(P <0.05). The DILI reports about acitretin capsule and tripterygium glycosides tablet were with the largest number of people. Conclusion Drugs in treatment of psoriasis have a certain risk of liver injury, which should be paid close attention in clinical diagnosis and treatment. Latency period of liver injury caused by TCM is slightly longer than that of western medicines. After taking drugs related to psoriasis treatment, patients should monitor liver function timely and early, and be alert to the risk of liver injury caused by the combination of Chinese and western medicines.

Key words: psoriasis, drug-induced liver injury, clinical characteristics, medication features