Abstract: Objective Through analyzing drug-induced liver injury (DILI) case reports associated with preparations containing Tripterygium Wilfordii (Lei Gong Teng, LGT), to investigate its characteristics of clinic and medication, and to provide reference for the rational drug use and safety evaluation on preparations containing LGT in clinical application. Methods To analyze and reevaluate characteristics of clinic and medication of preparations containing LGT reported between January 2012 and December 2016. Results A total of 251 DILI case reports associated with preparations containing LGT were collected during 5 years, whose age range was from 6 to 89 years old, with the concentrating distribution of age group from 41 to 60. Preparations containing LGT were mainly used for urinary system diseases, skin diseases, rheumatic diseases, etc, by analyzing the reasons for medication of 153 cases. The period of taking the preparations containing LGT until DILI occurring was from 0 to 1 793 days with the median of 12 days, and the range of daily dose was from 6 to 180 mg, with the median of 60 mg. From the analysis of rational drug use, we found that there were 25 cases with the prolonged treatment beyond prescribed course, 3 cases belonging to contraindication in people, and 9 cases with overdose respectively. Conclusion Preparations containing LGT were effective for urinary system and rheumatic immune diseases. However, under the premise of rational drug use, we should pay more attention to its duality of toxicity and effect and risk-benefit assessment while remind patients to detect their liver biochemical indexes regularly, which could guard against the risk of DILI, as well as improve the level of safe drug use in clinical application.

Key words: preparations containing Tripterygium Wilfordii, drug-induced liver injury, clinical characteristic, rational drug use.