Effects of Ioversol, Iodixanol, Iopromide on Renal Function in Patients with Early Diabetic Nephropathy

Abstract

Abstract: Objective To observe the effects of ioversol, iodixanol and iopromide on renal function in patients with early diabetic nephropathy. Methods 163 cases of patients with early diabetic nephropathy(DN) that prepare for enhanced CT examination were randomly divided into group ioversol group, iodixanol group and iopromide group. The blood urea nitrogen(BUN), creatinine(Scr) and urinary albumin/creatinine ratio(mAlb·Cr-1) were checked before and 5 days, 10 days after the CT scan. The glomerular filtration rates(eGFR) were calculated. The renal function indexes, incidences of contrast nephropathy were compared. Results The levels of SCr, BUN and mAlb·Cr-1 after 5 days of enhanced CT examination were higher than that before the examination in the 3 groups (P <0.05). The eGFR was lower than that before the examination (P <0.05). The mAlb·Cr-1, eGFR of ioversol group and iopromide group after 10 days of enhanced CT examination did not recover the levels before the examination. The SCr and mAlb·Cr-1 of iodixanol group were significantly lower than that of ioversol group 5 days after CT examination (P <0.05). The eGRF was significantly higher than that of ioversol group (P <0.05). The SCr of iopromide group was significantly lower than that of ioversol group (P <0.05). The eGRF was significantly higher in ioversol group (P <0.05). The incidence of CIN was significantly higher in ioversol group than in iodixanol and iopromide group (P <0.05). The incidence of CIN was significantly higher in iopromide group than in iodixanol group (P <0.05). Conclusion Low-osmolality iodinated contrast media can reduce the incidence of CIN in patients with early DN. If the osmolality is similar, as the viscosity of the contrast media increases, the incidence of contrast nephropathy increases.

Key words: contrast-induced nephropathy, diabetic nephropathy, ioversol, iodixanol, iopromide

CLC Number:

R981

WANG Shengqi, WANG Aidan. Effects of Ioversol, Iodixanol, Iopromide on Renal Function in Patients with Early Diabetic Nephropathy[J]. Chinese Journal of Pharmacovigilance, 2019, 16(4): 199-202.

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