Abstract: Objective To investigate the effects and mechanism of 4-methylcyclopentadecanone(4-MCPC) on myocardial ischemia/reperfusion(MI/R) injury on rat model. Methods MI/R rat model was established by coronary artery ligation for 30 min followed with 2 h reperfusion. Muscone was selected as control. Myocardial ischemic infarction was calculated and the level of CK, LDH in serum, the activity of MPO and the content of TNF-α, IL-1β in heart homogenate were detected to evaluate the effects of 4-MCPC on MI/R rats. Results Compared with model group, the myocardial ischemic infarction, CK, LDH level in serum, the activity of MPO and the content of TNF-α, IL-1β in heart homogenate were dramatically decreased in 4-MCPC(20, 10 mg·kg^-1) group rats. Conclusion 4-MCPC displayed certain protective effects on MI/R rat model.

Key words: 4-MCPC, ischemia/reperfusion injury, inflammation reaction, rat