Comparison of Sedative Effect and Safety of Midazolam and Dexmedetomidine on ICU Patients with Long-term Mechanical Ventilation

Abstract

Abstract: Objective To compare the safety between midazolam and dexmedetomidine on ICU patients with long-term mechanical ventilation. Methods A total of 120 cases of ICU patients with long-term mechanical ventilation were randomly divided into the dexmedetomidine group (the observation group) and midazolam group (the control group). The patients in control group were given midazolam, while the patients in observation group received dexmedetomidine. Sedative effect, analgesic effect and incidence of adverse reactions of patients in two groups were compared. Results Duration of mechanical ventilation and the dosage of remifentanil of patients in observation group significantly lower than those of control group (P <0.05). Analgesic effect of patients in the observation group significantly higher than that in the control group (P <0.05). The time required to achieve the desired sedation and recovery time of patients in the observation group were significantly shorter than those in the control group (P <0.05). Incidence of adverse reactions of patients in the observation group significantly lower than those in the control group (P <0.05). Conclusion Compared with the traditional midazolam regimen, dexmedetomidine was associated with more analgesic effect, lower duration of mechanical ventilation and the dosage of remifentanil, shorter time required to achieve the desired sedation and recovery time, lower incidence of adverse reactions, hypotension and tachycardia in patients with long-term mechanical ventilation, which is worth clinical promotion.

Key words: dexmedetomidine, midazolam, ICU patient, mechanical ventilation, safety, sedative effect

CLC Number:

R971.2

YANG Bo, ZHAO YU-liang, ZHOU Wen-bo, WANG Xu-dong, JIANG Jun-hao, LIU Hai-sheng. Comparison of Sedative Effect and Safety of Midazolam and Dexmedetomidine on ICU Patients with Long-term Mechanical Ventilation[J]. Chinese Journal of Pharmacovigilance, 2018, 15(3): 140-143.

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