Analysis of 737 Reports of Adverse Drug Reactions Induced by Zedoray Turmeric Oil Injection and Literature Review

Abstract

Abstract: Objective To study the features and contributing factors of adverse drug reactions(ADRs) induced by Zedoray turmeric oil injection and provide rational use of drugs in clinic. Methods 737 reports of ADRs induced by Zedoray turmeric oil injection were statistically analyzed from 2006 to 2016 in ADR monitoring database of Shandong province. Meantime, articles were reviewed and from different aspect，the possible influence links were explored. Results Occurring younger and faster, good prognosis were its feature. Group of children under 10-year-old accounted for the highest proportion of 51.42%, also, all patients were cured and no deaths occurred. Serious adverse reactions mainly included respiratory damage, of which dyspnea and cyanosis accounted for 84.35%, followed by systemic damage, skin damage and appendages damage, central and peripheral nervous system damage, gastrointestinal system damage and so on. Conclusion The causes of ADRs induced by Zedoray turmeric injection are complicated, what should be considered include raw materials, solubilizers used as accessories, production processes, clinical factors, storage and transportation .

Key words: Zedoray turmeric oil injection, adverse reaction, features

CLC Number:

R994.11

CHANG Hong, , WU Shi-fu, LI Yu-ji, XU Kui, GUO Fan-ling, CHANG Guang-jin, TANG Dao-quan. Analysis of 737 Reports of Adverse Drug Reactions Induced by Zedoray Turmeric Oil Injection and Literature Review[J]. Chinese Journal of Pharmacovigilance, 2017, 14(6): 359-363.

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