Abstract: Objective To investigate the clinical efficacy of Jiangzhiligan granules combined with simvastatin in the treatment of non-alcoholic fatty liver disease (NAFLD).Methods 86 patients with NAFLD from January 2014 to December 2015 in our hospital were selected and divided into control group (43 cases) and research group (43 cases) by the random number table method. Patients in the control group were given simvastatin tablets, while the research group was treated with the supplementary Jiangzhiligan granules. The treatment course of the two groups was both 3 months. The changes of liver biochemical indexes and serum lipid before and after the treatment were observed, the clinical efficacy of the two groups was evaluated.Results Compared with the levels before treatment, the ALT, AST, GGT in both of the two groups decreased significantly after 3 months treatment, and the changes of the observation group were more obvious, the difference was statistically significant (P < 0.05). The TG, TC, LDL-C in both of the two groups decreased significantly, and the HDL-C increased significantly after treatment, the changes of the research group were more obvious, the difference was statistically significant (P < 0.05). The SOD in both of the two groups increased significantly, and the MDA decreased significantly after treatment, the changes of the research group were more obvious, the difference was statistically significant (P < 0.05). The total effective rate in the observation group was 90.70%, which was significantly higher than that in the control group of 72.09%, the difference was statistically significant (P <0.05). No adverse reactions were found in the two groups after treatment, and the safety was good.Conclusion Jiangzhiligan granules combined with simvastatin can significantly improve liver biochemical indexes and serum lipid of patients with NAFLD, and has good safety and clinical value.

Key words: Jiangzhiligan granule, simvastatin, non-alcoholic fatty liver disease, clinical efficacy