Abstract: Objective To present the treatment of two essential thrombocythemia (ET) patients during gestation period and perinatal period, and analyze the rational medication. Methods Evaluated two ET patients, and individualized therapies were given during the gestation period and perinatal period according to the risk stratification. Results To the high risk patient, low molecular weight heparin (LMWH) and interferon α-2 b were applied during the whole gestation period; to the low risk patient, aspirin and interferon α-2 b were applied during the whole gestation period. Both patients delivered the fetus successfully, and LMWH was used from 12 hours to 6 weeks after delivery. Conclusion ET patients during gestation period and perinatal period are at high risk of complications. Evaluation of the prognosis, individualized treatment and rational drug use is required, by the cooperation of hematologists and obstetrists.

Key words: essential thrombocythemia, gestation period, rational drug use