Abstract: Objective To investigate the relationship of oxidative damage mechanism on hepatic toxic injury caused by volatile oil from Evodia Fructus in mice. Methods Mice were administrated with volatile oil from Evodia Fructus for 7 days, and the high, middle and low dose groups were separately set 1.25, 1.0, 0.25 mL·kg^-1. The level of MDA、SOD、NO、NOS、GSH、GSH-Px in serum and hepatic tissue were detected after administration of 7 d. Results The volatile oil from Evodia Fructus could cause the increased activity of MDA in serum and liver, reduced level of SOD, however, the level of NO and NOS were increased. In addition to the reduced activity of GSH and GSH-Px, all the changes were aggravated in accordance with the dosages. Conclusion The continuous administration of volatile oil from Evodia Fructus on mice can induce obvious hepato toxicity injury. The approach of hepatic damage is related with the peroxidative damage mechanism.

Key words: Evodia Fructus, volatile oil, hepatotoxicity, oxidative damage