Abstract: ObjectiveTo observe state of epidemic of the pathogenic bacterial and condition of usage of antibiotics in order to provide theoretical basis for reducing drug resistance and evidence for clinicians to choose antibiotics appropriately in our hospital. MethodsTop ten varieties of pathogenic bacterial and results of antimicrobial susceptibility test of positive samples in our hospital from 2008 to 2011 were collected. Defined daily doses(DDDs) of antibiotics which were commonly used were also analyzed. Results7 500 bacterial strains were isolated from 2008 to 2011. The number of top ten pathogenic bacterial strains were 5 066, accounting for 67.55%, in which the ration of gram-negative bacterial and gram-positive bacterial was 74.3% and 25.64%, respectively. Among gram-positive bacteria, staphylococcus aureus and staphylococcus epidermidis were only sensitive to vancomycin and linezolid. They showed low sensitivity to clindamycin, penicillin and erythromycin, among which cross drug resistance existed. A serious drug resistance existed among gram-negative bacterial. The sensitive rate of second-generation,third-generation cephalosporin and quinolones was below 50%, but carbapenems and several synthetic penicillins adding enzyme inhibitor showed a high sensitivity to them.The DDDs of quinolones, cephalosporin, lincosamides which were commonly used in our hospital were kept in the forefront of ranking. Vancomycin, imipenem /cilastatin and linezolid presented a quickly increasing trend. ConclusionOn the whole, the use of antimicrobial drugs in our hospital is rational. But more attention to drug sensitivity and use method of certain bacterial strains should be paid. Pharmacists should periodically concern the prevalence of pathogenic bacteria in their hospital and master the information about distribution of pathogens,drug sensitivity and usage of antibacterial drugs. Communication and cooperation between pharmacists and other healthcare professionals play an important role in promoting the rational use of antimicrobial agents in clinic.

Key words: antimicrobials, rational drug use, pathogen prevalence