Abstract: Objective To investigate the compatible stability of cefotaxime sodium and ornidazole chloride sodium injection. Methods The contents and absorption curves of cefotaxime sodium and ornidazole sodium chloride injection after mix were determined by ultraviolet spectrophotometry. The appearance of the solution was observed and pH value was determined. Results The absorption peaks of cefotaxime sodium and ornidazole sodium chloride injection were at 236 nm and 319 nm, respectively. The mixture changed from light yellow clear liquid to pale pink at 40min.There were no evident changes in appearance, pH, content and absorption curves during4 hours. Conclusion The solution might change in color after cefotaxime sodium and ornidazole sodium chloride injection were mixed. Such compatibility should be avoided in the clinic.

Key words: cefotaxime sodium, ornidazole, ultraviolet spectrohotometry, stability