Abstract: Objective To investigate the effect of the screening and training on Morris water maze memory performance of mice in order to offer the references and research ideas for impaired memory model. Methods Normal mice were divided into different groups such as the normal group with screening and training, model group with screening and training, normal group except screening and training, model group except screening and training and Positive drug control group. The screening and training group had Morris water maze test before the formal experiment to make sure every mice could find the platform in the provision of time. The ability of learning and memory were observed using Morris water maze. Results Screening and training of mice hada significant impact on the Morris water maze test, it could significantly shorten the latency and improve the ability of learning and memory in mice. Conclusion For the Morris water maze performance, the dementia model induced by scopolamine should be screened and trained before the formal experiment, so that the accuracy of the Results could be greatly improved.

Key words: Key word: screening and training, Morris water maze