Abstract: Objective To explore the features and contributing factors of adverse drug reaction(ADR) induced by receptor antagonist and aims to provide reasonable suggestions in the clinical medication. Methods A statistical analysis was conducted on 44 ADR cases induced by 5-HT3 receptor antagonist, publicly reported during the years from January 2000 to December 2011. Terms like "Ondansetron Hydrochloride", "Granisetron Hydrochloride", "Tropisetron", "Azasetron hydrochloride", "Ramostetron Hydrochloride" and "5-HT3 receptor antagonist" were searched in major domestic journals and databases, such as VIP Medical Information Resources Service System, Wanfang Data Medical Information System, Journals of Chinese Medical Association, and Chinese Hospital Digital Database. Results of all the 44 ADR patients, 20 of them are male, accounting for 45.45% and 24 of them are female, comprising 54.55%. The ADR cases induced by Granisetron Hydrochloride reach up to 30(68.18%), and ADR was chiefly observed on skin, accessories, the cardiovascular system and the respiratory system. Conclusion High attention should be paid on the ADR related to 5-HT3 receptor antagonist in clinic in order to ensure the safe medication.

Key words: 5-HT3, antagonist, adverse drug reaction(ADR)