Myoclonus Caused by Pregabalin in Patients with Herpes Zoster Neuralgia and Literature Analysis

doi:10.19803/j.1672-8629.2021.04.19

Abstract

Abstract: Objective To investigate the safety and pharmaceutical care of pregabalin used in combination with CCB antihypertensive drugs. Methods Based on one case of pregabalin-induced myoclonus in a patient with herpes zoster neuralgia, the clinical pharmacist reviewed domestic and foreign literature, studied the characteristics of the disease and medication, analyzed the causes of myoclonus in the patient, and summarized the bottom line of prevention of adverse reactions and pharmaceutical care for clinical reference. Results The clinical pharmacist proposed that the combination of pregabalin and CCB antihypertensive drugs be used with caution. Conclusion It is essential that clinical pharmacists participate in the monitoring of clinically-used drugs, which can contribute to drug safety of patients and prevention of adverse reactions.

Key words: herpes zoster neuralgia, pregabalin, calcium channel antagonist, adverse drug reaction

CLC Number:

R994.1

CAI Jiangxia, DU Xian, SUN Peihuan, ZHANG Xiaoying, LIU Tao, YE Yinmei. Myoclonus Caused by Pregabalin in Patients with Herpes Zoster Neuralgia and Literature Analysis[J]. Chinese Journal of Pharmacovigilance, 2021, 18(4): 381-383.

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