Abstract: In order to further understand the types of ototoxic drugs and the mechanism of deafness, and to explore the prevention and treatment strategies of drug -induced deafness, literatures about drug -induced deafness at home and abroad in recent years were collected, summarized and analyzed. The ototoxicity of drugs is related not only with hereditary, dose, length of time and administration route, but also with age and physical condition. The ototoxic drugs involve many kinds of chemicals and they will cause unimaginably serious consequence. More attention should be paid in clinical practice,clinical rational drug use should be strengthened. Prevention first and appropriate treatment as early as possible are the therapeutic strategies of the drug-induced deafness.

Key words: drug-induced deafness, ototoxicity, aminoglycosides, rational drug use