Abstract: Objective To understand the international research situations of the risk of proton pump inhibitors in long-term medication. Methods Using "proton pump inhibitors", "risk", "Meta" as key words to search CNKI, Pubmed database, and to collect and review the related literatures. Results and Conclusion The long -term use of proton pump inhibitors may cause a lot of risks, such as fracture, respiratory infection, spontaneous peritonitis, and clostridium difficile bacteria infection, ect. The proton pump inhibitors treatment should be combined with the comprehensive consideration, and try to avoid the clinical risks by proton pump inhibitors in long-term medication.

Key words: proton pump inhibitors, long-term medication, clinical risk