Immunotoxicity of traditional Chinese medicine containing Polygoni Multiflori Radix based on clinical signals

doi:10.19803/j.1672-8629.20220066

Abstract

Abstract: Clinically, most of the liver injuries caused by Polygonum multiflorum Thunb. and its preparations are immune specific liver injuries. The clinical risk signal mining of this type of liver injury focuses on specific constitution, basic diseases, gene markers, immune group libraries and serum metabolites. The onset of immune specific liver injuries is hidden and difficult to identify. This tentative exploration and mining of the immunotoxicity of Chinese herbal medicine containing Polygonum multiflorum Thunb. is expected to help clarify the priorities of subsequent clinical trials and provide reference for mining of clinical risk signals and the establishment of an early warning model of liver injury caused by Polygonum multiflorum Thunb.

Key words: Polygonum multiflorum Thunb., immune-specific, liver injury, clinical risk signals, immunotoxicity

CLC Number:

R961
R994

LEI Chao, WANG Zhifei, XIE Yanming. Immunotoxicity of traditional Chinese medicine containing Polygoni Multiflori Radix based on clinical signals[J]. Chinese Journal of Pharmacovigilance, 2022, 19(12): 1384-1387.

Add to citation manager EndNote|Ris|BibTeX

URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20220066

https://zgywjj.magtechjournal.com/EN/Y2022/V19/I12/1384

References

[1] YU RL, MEN WJ, ZHOU K, et al.Research progress on toxic material basis and hepatotoxicity mechanism of polygonum multiflorum[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(8): 496-503.
[2] LIN Y, XIAO R, LI C, et al.Research progress on chemical constituents, pharmacology and hepatoxicity of raw, processed and fermented Polygonum multiflorum Thunb.[J]. Traditional Chinese Drug Research and Clinical Pharmacology(中药新药与临床药理), 2018, 29(5): 661-672.
[3] DING L.Effect of Polygonum multiflorum Thunb. on hyperlipidemia[J]. Contemporary Medicine Forum(当代医药论丛), 2015, 13(21): 23.
[4] LI LC, WU XD, TIAN WX.Inhibition to fatty acid synthase with extract of tuber fleeceflower root[J]. Chinese Journal of Biochemistry and Molecular Biology(中国生物化学与分子生物学报), 2003(3): 297-304.
[5] WU XQ, CHEN XZ, LIU RY, et al.Anti-osteoporosis effects induced by retinoic acid in mice of hexane extract from raw and processed polygonum multiflorum[J]. Natural Product Research and Development(天然产物研究与开发), 2018, 30(12): 2175-2179.
[6] YU RL,MEN WJ,ZHOU K, et al.Research progress on toxic substance basis and hepatotoxic mechanism of Polygonum multiflorum[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(8): 496-503.
[7] LI MQ, PEI TR, HAN ZJ, et al.Research on immunogenicity and immunotoxicity of alliin[J]. Journal of Modern Medicine & Health(现代医药卫生), 2019, 35(20): 3122-3124.
[8] XIAO XH, GUO YM, WANG JB, et al.Scientific evaluation and risk prevention of herb induced liver injury:a case study of polygonum multiflorum[J]. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases(中西医结合肝病杂志), 2021, 31(3), 193-196.
[9] WANG J, MA Z, NIU M, et al.Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum[J]. Frontiers of Medicine, 2015, 9(4): 457-467.
[10] JING J, ZHU Y, SONG XA, et al.Clinical characteristics and diagnostic methods of liver injury induced by Chinese and western medicines[J]. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases(中西医结合肝病杂志), 2018, 28(5): 312-315.
[11] ZHU Y, NIU M, CHEN J, et al.Hepatobiliary and pancreatic: comparison between Chinese herbal medicine and western medicine-induced liver injury of 1985 patients[J]. Journal of Gastroenterology and Hepatology, 2016, 31(8): 1476-1482.
[12] BAI ZF, GAO Y, ZUO XB, et al.Progress in research on the pathogenesis of immune regulation and idiosyncratic drug-induced liver injury[J]. Acta Pharmaceutica Sinica(药学学报), 2017, 52(7): 1019-1026.
[13] LI N, SONG J, LI XF, et al.Influence of drug metabolizing enzyme inhibitors on liver injury susceptibility to trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside[J]. Acta Pharmaceutica Sinica(药学学报), 2017, 52(7): 1063-1068.
[14] WANG JB, LI CY, ZHU Y.Integrated evidence chain-based identification of Chinese herbal medicine-induced hepatotoxicity and rational usage: exemplification by Polygonum multiflorum (He shou wu)[J]. Chin Sci Bull, 2016, 61(9): 971-980.
[15] ZHU Y, LIU HS, WANG JB, et al.Clinical analysis of drug-induced liver injury caused by polygonum multiflorum and its preparations[J]. Chinese Journal of Integrated Traditional and Western Medicine(中国中西医结合杂志), 2015, 35(12): 1442-1447.
[16] TU C, GE FL, GUO YM, et al.Analysis of clinical characteristics and medication rationality of Polygonum multiflorum Thunb. and its preparation-related liver injury[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(5): 270-276.
[17] LI CY, LI XF, TU C, et al.The idiosyncratic hepatotoxicity of Polygonum multiflorum based on endotoxin model[J]. Acta Pharmaceutica Sinica(药学学报), 2015, 50(1): 28-33.
[18] SUN M, JIANG ZZ, YU QW, et al.Liver injury and rational use of Polygonum multiflorum Thunb.[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药杂志), 2021, 14(4): 175-177.
[19] JIA YT, MA TX, SHI PQ, et al.Liver damage caused by Chinese materia medica[J]. Journal of Gansu University of Chinese Medicine(甘肃中医药大学学报), 2020, 37(2): 100-103.
[20] WANG G, LIU Y, HOU XF, et al.Discussion on influence factors, mechanism and traditional Chinese medicine pathogenesis of idiosyncratic drug-induced liver injury[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2017, 42(16): 3036-3043.
[21] JING J,WANG RL, ZHAO XY, et al.Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb - Polygonum multiflorum Thunb. induced liver injury: a case – control study from a specialised liver disease center in China[J]. BMJ Open, 2019, 9(1): e023567.
[22] Branch of Chinese Patent Medicine, China Association of Chinese Medicinek, Branch of Hepatobiliary Diseases, China Association of Chinese Medicine, Committee of Clinical Chinese Pharmacy, Chinese Pharmaceutical Association, et al. Guidelines for safe use of Polygoni Multiflori Radixl[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2020, 45(5): 961-966.
[23] MEDINA-CALIZ I,ROBLES-DIAZ M,GARCIA-MUNOZ B,et al.Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury[J]. J Hepatol, 2016, 65(3): 532-542.
[24] WANG HY, LIU YQ, TIAN L, et al.New progress in omics biomarkers of drug-induced liver injury[J]. Chinese Journal of New Drugs and Clinical Remedies(中国新药与临床杂志), 2019, 38(1): 10-14.
[25] LI C, RAO T, CHEN X, et al.HLA-B*35:01 allele is a potential biomarker for predicting polygonum multiflorum-induced liver injury in humans[J]. Hepatology, 2019, 70(1): 346-357.
[26] HUANG DL, LI CP, WANG JB, et al.Validation of the correlation between the drug-induced liver injury caused by Polygonum multiflorum and the HLA-B*35:01 allele[J]. Chinese Journal of Liver Diseases,(中华肝脏病杂志), 2021, 29(11): 1106-1108.
[27] SHI W, GAO Y, GUO YM, et al.Idiosyncratic hepatotoxicity evaluation of Cortex Dictamni based on immune stress[J]. Acta Pharmaceutica Sinica(药学学报), 2019, 54(4): 678-686.
[28] WANG JB, CUI HR, BAI ZF, et al.Precision medicine-oriented safety assessment strategy for traditional Chinese medicines: disease-syndrome-based toxicology[J]. Acta Pharmaceutica Sinica(药学学报), 2016, 51(11): 1681-1688.
[29] RAO T, LIU YT, ZENG XC, et al.The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury[J]. Acta Pharmacol Sin, 2021, 42(1): 27-35.
[30] MA KF, ZHANG XG, JIA HY.CYP1A2 polymorphism in Chinese patients with acute liver injury induced by polygonum multiflorum[J]. Genet Mol Res, 2014, 13(3): 5637-5643.
[31] QUAN ZY, LI DK, LI YQ, et al.CYP1A2 depletion by shRNA enhances hepatotoxicity of extract of polygoni multiflori radix and related monomer compositions[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(3): 213-219.
[32] REN SC, ZHANG YG, DAI Y, et al.Study on immune repertoires and prospect its application in traditional Chinese medicine[J]. Pharmacology and Clinics of Chinese Materia Medica(中药药理与临床), 2018, 34(1): 178-183.
[33] SHI XS, LI LY, GUO XD, et al.Structural and functional studies of T cell receptor[J]. Chinese Journal of Cell Biology(中国细胞生物学学报), 2011, 33(9): 955-963.
[34] LIU FM, XIE YM, WANG ZF, et al.TCR immune repertoire characteristics of patients with drug-induced liver injury due to polygonum multiflorum preparations[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2019, 44(20): 4397-4404.
[35] LI CY, HE Q, TANG JF, et al.Metabolomic study on immunological stress-mediated hepatotoxicity of polygonum multiflorum and its processed products of nine times steaming and nine times sunning[J]. Acta Pharmaceutica Sinica(药学学报), 2017, 52(7): 1069-1076.
[36] ZHOU YY, NIU M, TU C, et al.Metabolomic study on the susceptible factors of idiosyncratic traditional Chinese Medicine-induced liver injury: exemplification of a polygonum multiflorum preparation[J]. Chinese Science Bulletin(科学通报), 2019, 64(9): 948-962.
[37] BUCK MD, SOWELL RT, KAECH SM, et al, Metabolic instruction of immunity[J]. Cell, 2017, 169(4): 570-586.
[38] ZHANG L, NIU M, WEI AW, et al.Individual identification of liver injury of Polygonum multiflorum Thunb. based on metabolomics[C]. Ninth National Congress of Toxicology, Chinese Society of Toxicology(中国毒理学会第九次全国毒理学大会), 2019: 58.