Analysis of 114 Cases of ADR Induced by PPI

Abstract

Abstract: Objective To explore the features and contributing factors of adverse drug reaction(ADR) induced by proton pump inhibitors (PPIs) and provide rational use of drugs in clinic. Methods A statistical analysis was conducted on 114 cases of ADR publicly reported during the year from January 2001 to December 2011 via the use of VIP Medical Information System(VMIS), Wanfang Medical Information System, and Chinese Hospital Digital Database. Results Of all the 114 cases, male patients amount to 72, accounting for 63.16%; Female 42 cases, comprising 36.84%. The ADR induced by Omeprazole reach up to 79 cases, making up 69.30%, and clinic ADR is mainly observed on the nervous system, the digestive system and the cardiovascular system. Conclusion High importance should be attached to the ADR induced by PPIs in clinic to ensure the safe use of drugs.

Key words: PPI, ADR, literature

CLC Number:

LIANG Mao –ben, MENG Xiang –mei. Analysis of 114 Cases of ADR Induced by PPI [J]. Chinese Journal of Pharmacovigilance, 2013, 10(1): 39-41.

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