Abstract: Objective To survey the cases of hypoglycemia deaths caused by glibenclamide and analyze the relevant factors, provide a reference for the clinical use of drugs. Methods37 cases of glibenclamide-induced hypoglycemia deaths were statistically analyzed. ResultsMale to female ratio was 1.6:1,87.8% of cases for the elderly(>60), 86.5% of the patients had non-standard situation of drug use, 8.1% single drug, 75.7% of cases combined use of drugs, 100% of the cases are different degrees of clinical symptoms of low blood sugar coma, 54.1% of the cases were not discovered in time, misdiagnosed or missed. There are many reasons of death, 56.8% of death cases are caused by prolonged hypoglycemic coma with multiple organ failure or respiratory, circulatory failure. ConclusionHypoglycemic coma caused by glibenclamide can cause great harm. Hypoglycemic drugs should pay attention to safety. When we use this drug, we must carefully consider the age, usage, dosage and other relevant factors, then make rational use of drugs to reduce the incidence of low blood sugar reactions.

Key words: glibenclamide, drug-induced hypoglycemia, death, rational drug use