Chinese Journal of Pharmacovigilance ›› 2011, Vol. 8 ›› Issue (12): 753-754.

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Analysis on 748 Cases ofβ-lactam Antibiotics Drug Adverse Reaction

ZHANG Shu-qiang1, XING Rong2, *, WANG Qun2, SHI Pei-lan2, XIE Dong-mei2, XU Jian2   

  1. 1 Adverse Drug Reactions Monitoring Center of Bengbu Region, Anhui Bengbu 233000, China;
    2 First Affiliated Hospital of Bengbu Medical College, Anhui Bengbu 233000, China
  • Received:2011-05-04 Online:2011-12-10 Published:2015-07-30

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Abstract: Objective To investigate the situation of β-lactam antibiotics drug adverse reactions in Bengbu region. Method According to gender, age, administration route, drug category, organs or systems, clinical manifestations Involved with ADR, and so on, 748 cases of β-lactam antibiotics drug adverse reactions in Bengbu region reported from Jan 2010 to Dec 2010 were analyzed. Results 26 β-lactam antibiotics drugs were involved with ADR. As to the ADR frequence, the highest was related to amoxicillin, and then were related to cephalexin and cephradine. The major organ-system damage involved in ADR was skin and appendages disorders, which accounted for 47.48% of the total, and a serious ADR occurred. Conclusion Clinical appliance of β-lactam antibiotics drug should be standardized to reduce the ADR incidence.

Key words: β-lactam antibiotics drug, adverse drug reaction(ADR), drug combination

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