Abstract: Objective To explore the warning signal, improve the quality of adverse drug reaction(ADR) supervision and promote clinical drug safety through the statistical analysis of adverse drug reaction(ADR). Methods Choose the new & serious 405 ADRs cases in Baoshan District from January to June in 2010 as a sample, on which do statistical analysis in various ways by EXCEL and manual screening. Results In the 405 cases, including 192 cases who are over 60a(47.1%), ADRs are mainly caused by Chinese patent medicines(37.8%), anti-microbiology medicine(33.9%) and intravenous injection(57.7%). ADRs mainly affects the digestive system, skin and nervous system ,which respectively accounted for 34.1%,22.3% and 20.9%. Conclusion ADRs are caused by many factors, including patient`s age, drug types and the way of use, It must pay great attention to Chinese patent medicines and anti-microbiology medicine. The clinical manifestation is also becoming more and more pluralistic. Therefore, we should strengthen the monitoring method and rational use of drugs to ensure medication safety and efficiency.

Key words: ADR, pharmacovigilance, rational drug use