Abstract: Objective To realize the incidence and damage of the adverse drug reactions(ADRs) in children and promote rational use of drugs in pediatric clinical practice. Methods We collected 262 cases of ADRs in our hospital from 2006 to 2010, and retrospectively analyzed and evaluated them. Results In the 262 cases, most of the ADRs occurred in the infants from 1 months to 3 years, accounting for 58.77%(154 cases)of the total number. Introvenous injection was with the highest incidence of ADRs, 97.3%(255 cases) of the total number. Among the used drugs, antibiotics had the highest incidence of ADRs, 55.34%(145 cases) of the total number. Most of the clinical symptoms were allergic reactions, skin and accessories injury. Conclusion ADRs can easily happen in infants. Antibiotics or intravenous injection is prone to causing ADRs. We should further strengthen the monitoring of ADRs in children so as to reduce or avoid the occurence of it.

Key words: children, adverse drug reactions(ADRs), rational drug use