Abstract: Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation、control and efficacy, and the research on the "dose-effect relationship" and "dose-toxicity relationship” about the toxicial components. Methods References in the last decades both at home and abroad about Cortex Periplocae were collated, analyzed and summarized. Results At present, Cortex Periplocae for efficacy, and toxicity of the material basis of the study to stay contained on the basis of cardiac glycosides, The pharma-cology and toxicology studies on the Cortex Periplocae not enough depth, whether on the Cortex Periplocae contain other material basis for efficacy and toxicity has been reported rarely. Conclusion The research on Cortex Periplocae about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction、the early diagnosis and treatment measures that can be referred to clinical usage. Cortex Periplocae will be ensured to use safety as a clinical drug.

Key words: Cortex Periplocae, efficacy, toxicity, material basis