Preventive Hypolipidemic Effect of Hongqu Dilong Tablets and Metabolic Regulation

doi:10.19803/j.1672-8629.20250639

Abstract

Abstract: Objective To investigate the preventive hypolipidemic effects and metabolic regulatory mechanisms of Hongqu Dilong tablets so as to provide a reference for subsequent research on the mechanism of action of such drugs and their safe clinical use. Methods A high-fat diet (HFD)-induced C57BL/6N mouse model was established. Mice, male or female, were orally administered Hongqu Dilong tablets (0.208 mg·g⁻¹) daily for 4 weeks. Body weight, serum levels of ALT, AST, blood lipids, glucose, and liver histopathology were assessed. Serum metabolomics was employed to explore metabolic alterations and potential mechanisms. Results Compared with the HFD model group, mice treated with Hongqu Dilong tablets had their body weight significantly reduced and liver function (ALT and AST) improved. The treatment markedly reversed HFD-induced elevations in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) while significantly reducing blood glucose levels in male mice. Histopathological examination (H&E and oil red O staining) revealed that the tablets alleviated hepatic lipid accumulation and mitigated HFD-induced structural abnormalities, including disorganized hepatocyte arrangement and expanded intercellular spaces. Metabolomic analysis suggested that the preventive hypolipidemic effects were mediated by regulating lipid metabolism and sphingolipid signaling pathways, along with modulations in amino acid and protein metabolism. Conclusion Hongqu Dilong tablets can effectively counteract HFD-induced increases in body weight, dyslipidemia, and hepatic lipid deposition in mice of both sexes. The mechanism may involve regulation of a metabolic network related to lipid metabolism.

Key words: Red Yeast Rice, Earthworms, Blood Lipids, Lipid Metabolism, Liver, Metabolomics, Mice

CLC Number:

R285
R972

LI Gaofu, WANG Ningning, SUN Yue, XIA Tiantian, ZHOU Wei, GAO Yue. Preventive Hypolipidemic Effect of Hongqu Dilong Tablets and Metabolic Regulation[J]. Chinese Journal of Pharmacovigilance, 2025, 22(12): 1352-1359.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250639

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I12/1352

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