Abstract: Objective To explore the pharmaceutical care strategy for a patient with acute pancreatitis complicated with multidrug allergy who underwent drug stimulation test, and to provide reference for pharmaceutical care of patients with multidrug allergy. Methods A clinical pharmacist participated in the consultation for a patient with acute pancreatitis complicated with multidrug allergy, analyzed the patient’s previous allergic history, recommended the drug provocation test to justify the diagnosis of drug allergy, and suggested medications based on the patient’s condition and results of the drug provocation test. Results The patient was diagnosed with acute pancreatitis complicated with infection. The standardized skin test of β-lactam antibiotics and the drug stimulation test of cefoperazone sulbactam were negative, so cefoperazone sulbactam (3 g q8h) was selected for anti-infection treatment. No allergic reactions occurred during the treatment. The clinical pharmacist provided whole-course pharmaceutical care for this patient. Conclusion The evaluation of drug sensitivity and allergy history and drug provocation tests are critical to the selection of antibiotics in patients with multiple drug allergy. Clinical pharmacists should assist doctors in formulating treatment plans and carrying out whole-process pharmaceutical care for patients so as to ensure the safety and effectiveness of drugs.

Key words: acute pancreatitis, multiple drug allergy, drug provocation test, antibacterial drugs, cefoperazone sulbactam, rational use, clinical pharmacist, pharmaceutical care