[1] MARCUCCI E,BARTOLONI E,ALUNNO A,et al.Extra-articular rheumatoid arthritis[J]. Reumatismo, 2018,70(4):212-224. [2] SMOLEN JS, ALETAHA D, BARTON A, et al.Rheumatoid arthritis.[J] Nat Rev Dis Primers. 2018 ; 4(1): 18001. [3] PANG YZ,LUO ZH,TANG QQ,et al.chinese medicine pathogenesis syndrome element of rheumatoid arthritis:discussion on bi-syndrome pathological factors[J].Journal of Traditional Chinese Medicine(中医杂志), 2018, 59(5):4. [4] ZHENG W,ZHU YL,MA JF,et al.Clinical observation on jiawei shaogan fuzi decoction combined with western medicine in the treatment of 30 rheumatoid arthritis patients with cold-damp obstruction syndrome at active phase[J].Journal of Traditional Chinese Medicine(中医杂志),2018,59(9):760-764. [5] MA JF,HOU XJ,LIU XP,et al.Establishment and evaluation of cold syndrome animal model with rheumatoid arthritis[J].China Journal of Traditional Chinese Medicine and Pharmacy(中华中医药杂志), 2016,31(5): 1967-1970. [6] SUN YQ.Effect and mechanism of aconite decocton on rheumatoid arthritis[D].China Academy of Chinese Medical Sciences(中国中医科学院),2012. [7] XU SY,BIAN RL, CHEN X.Experimental Methodology of Pharmacology (药理实验方法学)[M].Beijing ; People's Medical Publishing House , 2002: 23. [8] MAO X, ChEN WJ, LI YF , et al.An exploration into the therapeutic effects and molecular mechanisms of paeoniflorin in the treatment of adjuvant-induced arthritis rats by a network pharmacology-based research strategy[J].Acta Pharmaceutica Sinica(药学学报),2019,54(11):2000-2010. [9] SHAOX,YUAN YS,JIANG XH,et al.Effect of aconitine on proliferation, apoptosis and autophagy of fibroblast-like synoviocytes in rheumatoid arthritis[J].Chinese Journal of Immunology(中国免疫学杂志), 2019, 35(24): 3066-3070, 3074. [10] HU ZP, HE SQ, WANG CM, et al.Glycyrrhizic acid inhibits PI3K/AKT/NF-κB attenuating inflammatory response in collagen-induced rheumatoid arthritis rats[J].Chinese Journal of Gerontology(中国老年学杂志), 2020, 40(13): 2852-2856. [11] JING WX,ZHU YL,HOU XJ,et al.Intervention of angiogenesis in the rats of collagen induced arthritis treated with the therapy for warming meridians and circulating collaterals[J].World Journal of Integrated Traditional and Western Medicine(世界中西医结合杂志), 2013, 8(5): 502-506. [12] YUAN F,ZHU YL.Mechanism study of modified Shaogan Fuzi decoction on the angiogenesis inhibitor factors in the synovial of rats with collagen-induced arthritis[J].Beijing Journal of Traditional Chinese Medicine(北京中医药), 2014, 33(7): 551-554. [13] LIU Y, ZHU YL, HXJ,et al.Effects of modified Shaogan Fuzi decoction on angiogenesis relating factors in the synovial tissue of CIA rats[J].Global Traditional Chinese Medicine(环球中医药), 2015, 8(6): 692-696. [14] ZHANG YT,HOU XJ,LIU XP,et al.Effect of modified Shaogan Fuzi Decoction on the pathology of joint synovium and expression level of serum IL-2,IL-17A and TNF-ɑ in rats with collagen induced arthritis[J].Journal of Tianjin University of Traditional Chinese Medicine(天津中医药大学学报), 2021, 40(1): 93-97. [15] LIU XP, MA JF, ZHENG W,et al.IFN-γ and IL-17A in rats with CIA cold syndrome treated by modified Shaogan Fuzi decoction effect of expression[J]. Global Traditional Chinese Medicine(环球中医药), 2018, 11(2): 167-171. [16] BRZUSTEWICZ E, BRYL E.The role of cytokines in the pathogenesis of rheumatoid arthritis--practical and potential application of cytokines as biomarkers and targets of personalized therapy[J]. Cytokine. 2015, 76(2): 527-536. [17] SCHINNERLING K, AGUILLóN JC, CATALáN D, et al. The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis[J]. Clin Exp Immunol. 2017 , 189(1): 12-20. [18] ZHAO H,YANG QF,LI MQ.Advances in studies on toxicity of aconite[J].Hebei Journal of Traditional Chinese Medicine(河北中医), 2017, 39(5): 774-777. [19] KORVER S, BOWEN J, PEARSON K, et al.The application of cytokeratin-18 as a biomarker for drug-induced liver injury[J]. Arch Toxicol, 2021, 95(11): 3435-3448. [20] THULIN P, HORNBY RJ, AULI M, et al.A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat[J]. Biomarkers, 2017, 22(5): 461-469. [21] LEA JD, CLARKE JI, MCGUIRE N, et al.redox-dependent hmgb1 isoforms as pivotal co-ordinators of drug-induced liver injury: mechanistic biomarkers and therapeutic targets[J]. Antioxid Redox Signal, 2016,24(12):652-665. [22] CHEN Y, SUN W, GAO R, et al.The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis[J]. Rheumatology (Oxford), 2013 , 52(10): 1739-1747. [23] BARNAY-VERDIER S, GAILLARD C, MESSMER M, et al.PCA-ELISA: a sensitive method to quantify free and masked forms of HMGB1[J]. Cytokine, 2011 , 55(1): 4-7. [24] ABASSI Z, SAGI O, ARMALY Z, et al.Neutrophil gelatinase-associated lipocalin (NAGL): a novel biomarker for acute kidney injury[J]. Harefuah, 2011, 150(2): 111-116. |