Complex network analysis of combined regimens of Xiyanping injection in the treatment of hand-foot-mouth disease

doi:10.19803/j.1672-8629.2022.08.06

Abstract

Abstract: Objective To obtain the combined medication schemes of Xiyanping injection in the treatment of hand-foot-mouth disease in the real world. Methods The clinical data on patients with hand-foot-mouth disease treated by Xiyanping injection between December 1, 2006 and June 30, 2016 was collected from 28 large hospitals in China and analyzed with the Tabu search algorithm. Complex network modeling of large but high-quality data in the real-world research was attempted. Results The data on combined medications of a total of 19 999 patients was harvested. Based on the sub structure group of categories of core combinations with western medicine, the most frequently used combination was Xiyanping injection + vitamins, followed by Xiyanping injection + interferons and Xiyanping injection + immune enhancers. The most frequently used core combination with traditional Chinese medicine was Xiyanping injection + antipyretics, followed by Xiyanping injection + formula for resuscitation and Xiyanping injection + antipyretics or antidotes. Conclusion Xiyanping injection is often used in combination with other drugs in the treatment of mild and severe hand-foot-and mouth disease .

Key words: Xiyanping iniection, hand-foot-mouth (HFMD), complex networks, Tabu search algorithms, real world

CLC Number:

R969

DU Ying, WANG Zhifei, XIE Yanming, WANG Lianxin, LI Lixun, LIU Zhishuai. Complex network analysis of combined regimens of Xiyanping injection in the treatment of hand-foot-mouth disease[J]. Chinese Journal of Pharmacovigilance, 2022, 19(8): 839-844.

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