The real world Ciwujia injection for the treatment of emotional disorders analyzed based on data mining algorithm

doi:10.19803/j.1672-8629.2022.02.02

Abstract

Abstract: Objective To study the information about medications with Ciwujia injection in the treatment of emotional disorders based on the real-world data and summarize clinical medication schemes of Ciwujia injection. Methods A total of 1 093 patients who had been treated with Ciwujia injection between January 8, 2004 and August 22, 2014 were selected from the hospital information system of 16 big hospitals in China, and the information on their drug combinations was analyzed by using the tabu search (TS) algorithm. The clinical combination regimens of Ciwujia injection for patients with emotional disorders were screened out through drug analysis in the subnetwork. Results For patients with anxiety and depression accompanied by sleep disorders, Ciwujia injection + Bailemian capsules + halupentixil/paroxetine could be considered. The combination of Ciwujia injection + Wenxin granules + flupentixol could be chosen for patients with cardiac neurosis. Conclusion The combined application of Chinese and western medicines can help to improve efficacy and reduce side effects. On this basis, prospective clinical efficacy and safety evaluation can be conducted for a sub-network module.

Key words: Ciwujia injection, Tabu search algorithm, emotional disorder, combined medication, real world, post market evaluation, data mining

CLC Number:

R932R971

ZHANG Jiajia, ZHI Yingjie, XIE Yanming, SUN Linxi, ZHUANG Junni, ZHUANG Yan. The real world Ciwujia injection for the treatment of emotional disorders analyzed based on data mining algorithm[J]. Chinese Journal of Pharmacovigilance, 2022, 19(2): 121-125.

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