类风湿性关节炎动物模型的研究进展与中药药效评价思考

中国药物警戒 ›› 2014, Vol. 11 ›› Issue (4): 219-221.

类风湿性关节炎动物模型的研究进展与中药药效评价思考

栾永福¹, 孙蓉^2*

1天津中医药大学,天津 300073;
2山东省中医药研究院,山东济南 250014

收稿日期:2014-03-19 修回日期:2016-02-03 出版日期:2014-04-08 发布日期:2016-02-03
作者简介:栾永福,男,在读硕士,中药药理学。
基金资助:
国家重点基础研究发展计划（973）中医基础理论专项资助项目课题2（2009CB522802）,国家重大新药创制专项课题：中药复方药理学研究与药效评价关键技术（2009ZX09502-015）

Advances in Establishments of Animal Models with Rheumatoid Arthritis and Thinking about Efficacy Evaluation of TCM

LUAN Yong-fu¹, SUN Rong^{2, *}

1Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China;
2 Shandong Research Academy of Traditional Chinese Medicine, Shandong Jinan 250014, China

Received:2014-03-19 Revised:2016-02-03 Online:2014-04-08 Published:2016-02-03

摘要/Abstract

摘要： 目的介绍类风湿性关节炎模型的研究进展,进行中药药效评价思考。方法对近十几年来国内外相关文献对关节炎模型的报道进行整理、分析与归纳。结果与结论目前主要有佐剂性关节炎和胶原诱导性关节炎模型等,应该根据中药自身的特点选择合适的动物模型,进行候选药物筛选和药效评价,并将类风湿性关节炎动物模型的研究与临床疾病研究紧密地结合起来,为临床前中药药理研究与药效评价提供方法学保证。

关键词: 类风湿性关节炎, 动物模型, 研究进展

Abstract: Objective To introduce the research development on the establishments of animal models with rheumatoid arthritis, and think about efficacy evaluation of TCM. Methods References in the last decades at home and abroad about RA model were collated, analyzed and summarized. Results and Conclusion The main RA model are AA, CIA and so on. We should select suitable animal model on the basis of TCM's characteristic to screen out medicine and to evaluate the efficacy of medicine, and combine closely the research of RA's animal model with clinical disease to ensure the stability and reliability of animal model. And then to offer methodological ensurance for TCM's pharmacological preclinical research and efficacy evaluation.

Key words: rheumatoid arthritis, animal model, research progress

中图分类号:

R286
R285.5

栾永福, 孙蓉. 类风湿性关节炎动物模型的研究进展与中药药效评价思考[J]. 中国药物警戒, 2014, 11(4): 219-221.

LUAN Yong-fu, SUN Rong. Advances in Establishments of Animal Models with Rheumatoid Arthritis and Thinking about Efficacy Evaluation of TCM[J]. Chinese Journal of Pharmacovigilance, 2014, 11(4): 219-221.

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