中药中黄曲霉毒素B1污染概况

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (10): 608-616.

中药中黄曲霉毒素B1污染概况

赵祥升¹, 应光耀¹, 魏建和², 孙华³, 杨美华^2*

¹中国医学科学院北京协和医学院药用植物研究所海南分所,海南省南药资源保护与开发重点实验室,海南海口,570311;
²中国医学科学院北京协和医学院药用植物研究所,北京 100193;
³中国医学科学院北京协和医学院药物研究所,北京 100050

收稿日期:2018-09-18 修回日期:2018-11-27 出版日期:2018-10-20 发布日期:2018-11-27
通讯作者: 杨美华,女,博士,教授·博导,中药质量分析及安全性研究。E-mail: yangmeihua15@hotmail.com
作者简介:赵祥升,男,博士,副研究员,中药质量控制及安全性评价。
基金资助:
中国医学科学院医学与健康科技创新工程项目（2017-I2M-1-013）：中药安全风险预警及防控

Overview of Aflatoxin B1 Contamination in Traditional Chinese Medicine

ZHAO Xiangsheng¹, YING Guangyao¹, WEI Jianhe³, SUN Hua², YANG Meihua^3*

¹Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Hainan Haikou 570311, China;
²Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;
³Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China

Received:2018-09-18 Revised:2018-11-27 Online:2018-10-20 Published:2018-11-27

摘要/Abstract

摘要： 目的对中药中黄曲霉毒素B1（AFB1）的污染状况进行文献分析。方法对2000年以来国内外发表的中药中AFB1检测的阳性定量结果的文献进行整理,总结与分析。结果 149种中药（包含12种动物药,3种发酵药材）的1 168批样品中检测到AFB1。植物药中种子果实类,根茎类药材容易污染AFB1。阳性样品超标率（限量标准,5 μg·kg-1）达到52.40%,并且不同中药间AFB1的检测值差异较大。结论中药中AFB1污染已是普遍现象,未来应加强中药中AFB1检测方法、限量标准和防霉养护的研究。

关键词: 中药, 黄曲霉毒素B1, 毒性, 限量标准, 污染

Abstract: Objective To summarize aflatoxins B1 contamination in traditional Chinese medicines (TCMs). Methods References from 2000 to now at home and abroad about the positive Results of AFB1 in TCMs were collated, summarized and analyzed. Results AFB1 were detected in 1 168 batches of 149 TCMs (including 11 animal medicines and 3 fermented medicines). Compared with the other medical parts, fruits and seeds, roots and rhizomes were more easily contaminated with AFB1. The rate of exceed standard (limit standard, 5 μg·kg-1) in the positive samples reached 52.40%, and the detection values of AFB1 among the TCMs were different significantly. Conclusion Contamination of AFB1 in TCMs is common. In the future, research on detection menthod, limit standard and anti-mild maintenance of AFB1 in TCMs should be strengthened.

Key words: traditional Chinese medicine, aflatoxin B1, toxicity, limited standard, contamination

中图分类号:

R917

赵祥升, 应光耀, 魏建和, 孙华, 杨美华. 中药中黄曲霉毒素B1污染概况[J]. 中国药物警戒, 2018, 15(10): 608-616.

ZHAO Xiangsheng, YING Guangyao, WEI Jianhe, SUN Hua, YANG Meihua. Overview of Aflatoxin B1 Contamination in Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2018, 15(10): 608-616.

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