抗肿瘤药物的靶点毒性研究进展

摘要/Abstract

摘要： 近年来，随着药物化学、生命科学、分子生物学、分子药理学的飞速发展，全球肿瘤靶向治疗药物研发活跃，纷纷上市或者进入临床研究。随着与疾病相关的突变位点和信号通路的发现，出现了针对这些突变位点和信号通路的治疗方式，即靶向治疗。靶向治疗较传统药物更加精确、副作用小、适用性好、特异性高，但也出现了一系列与治疗靶点相关的毒性。本文按照药物的作用机制，总结归纳了目前具有代表性的抗肿瘤药物的靶点毒性的研究进展，期望对靶向治疗药物的安全性评价和研究提供参考信息。

关键词: 靶点, 毒性, 抗肿瘤药

Abstract: With the rapid development of medicinal chemistry, bioscience, molecular biology and molecular pharmacology, there are many anti-tumor drugs under research, coming into clinical trials or having been approved. With the discovery of disease-associated mutation sites and signaling pathways, therapeutic approaches to these mutations and signaling pathways have emerged, which is named targeted therapies. Targeted therapies are more accurate than conventional drugs with few side effects, good applicability, and high specificity. However, a series of toxicities associated with therapeutic targets have also emerged. According to the mechanism of action of drugs, this article has summarized the target related toxicity of anti-tumor drugs, and hopes to provide some ideas and suggestions for the safety evaluation of targeted therapy.

Key words: target, toxicity, antineoplastic agent

中图分类号:

R965

李红颖, 杨翠平，, 靳洪涛,. 抗肿瘤药物的靶点毒性研究进展[J]. 中国药物警戒, 2018, 15(3): 152-157.

LI Hong-ying, YANG Cui-ping,, JIN Hong-tao,. Research Progress of Target Related Toxicity of Anti-tumor Drugs[J]. Chinese Journal of Pharmacovigilance, 2018, 15(3): 152-157.

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