关键词: 三黄泻心汤, 炮制, 配伍, 药效学

Abstract: Objective To compare the pharmacodynamical actions of 9 component compatibility of processed Sanhuangxiexin decoction in terms of anti-inflammation, removing blood stasis and antipyretic effect, and the relationship between the composition and quantity ratio of chemical components from crude Raubarb, prepared Rhubarb and Rhubarb charcoal piece, based on the chemical composition compatibility of processed herbal pieces. Methods Rats were randomly divided into the following groups: control group, model group, positive medicine group(aspirin 0.2 g·kg^-1) and 9 component compatibility groups. The dose for the rat was 0.5 g·kg^-1 and 0.9 g·kg^-1 for the mouse. All groups were treated continuously for 7 days. The acute blood stasis syndrome model was established by hypodermic injection of adrenalin combined with ice water bath. The indexes of hemorheology including whole blood viscosity, plasma viscosity, packed red cell volume, platelet aggregation and fibrinogen were detected under the different shear rate. The thrombin time and prothrombin time were examined. The mouse ear swelling model induced by dimethylbenzene was used to observe the anti-inflammatory action, the volume of the ear swelling was measured after the modeling, and the degrees of swelling (E%) and inhibiting(I%) were calculated. The rat fever model was made by hypodermic injection of 15% yeast saline, the temperature was measured at 0.5, 1, 2 and 4 h after administration. Results The component compatibility of No.7 group decreased the whole blood viscosity and plasma viscosity more significantly, and the obvious decrease of ear swelling rates was found in No. 2, 4 and 8 group when compared to other component compatibility groups. Conclusion Based on the Results , No.7 and 8 group were considered as optimal compatibility of the 9 groups.

Key words: Sanhuangxiexin decoction, ocessed, component compatibility, pharmacodynamics