基于“通权达变”思想探究柴胡不同炮制方法

doi:10.19803/j.1672-8629.20240192

摘要/Abstract

摘要： 目的基于“通权达变”思想分析柴胡不同炮制品的古今用药经验及现代研究进展,为柴胡炮制机制及炮制工艺研究提供参考。方法从中华医典、读秀等数据库系统挖掘柴胡炮制方法的历史演变及柴胡饮片临床用药特色;通过查阅文献梳理柴胡不同炮制品的现代研究进展。结果历代医药典籍记载柴胡炮制品种丰富,不同炮制品功效上存在较明显差异：醋柴胡疏肝解郁之效增强,升散之性减弱;鳖血柴胡滋阴退热之效增强,浮阳之性减弱;酒柴胡舒筋通络、活血止痛之效增强。现代研究对柴胡不同炮制品的科学内涵进行了不同程度解读,但仍存在一些问题,如炮制工艺参差不齐、质量标准尚未统一等。结论柴胡药用历史悠久,临床应用广泛,炮制品种较多,亟需加强不同炮制品的药效物质基础及炮制机理的系统研究,加深对柴胡不同炮制品科学内涵认识,建议规范炮制工艺和制定更加科学合理的质量标准,为临床提供质量稳定可控、品种丰富的柴胡炮制品,发挥柴胡临床治疗的特色和优势。

关键词: 柴胡, 炮制, 醋柴胡, 鳖血柴胡, 炮制工艺, 通权达变

Abstract: Objective To analyze the ancient and modern experience concerning medications with Bupleuri Radix and recent research progress in processed products of this drug based on the idea of “Tong Quan Da Bian” so as to provide reference for the study of the processing mechanism and processing technology of Bupleuri Radix. Methods The evolution of processing methods of Bupleuri Radix and the way in which Bupleuri Radix decoction pieces were used clinically were retrieved from such databases as Chinese Medical Classics and Duxiu. Based on literature review, the current research progress in a range of processed products of Bupleurum chinense was analyzed. Results According to the records of medical classics, the processed products of Bupleuri Radix were diverse, and there were considerable differences in the efficacy of different processed products: the effect of soothing the liver and relieving depression by vinegar Bupleuri Radix was enhanced while the property of elevating and dispersing qi was weakened; the effect of nourishing yin and reducing fever by Bupleuri Radix processed with trionyx blood was enhanced, and the property of floating yang was weakened; the effect of relieving rigidity of muscle, activating collaterals and pain relief was enhanced. Modern research has interpreted the connotations of different processed products of Bupleuri Radix to different extents, but there are still some problems, such as variations in processing technology and inconsistent quality standards. Conclusion Bupleuri Radix has been long used as a medicinal herb, with wide clinical applications and varieties of processed of products. It is urgent to conduct systematic research on the pharmacodynamic material basis and processing mechanism of different processed products, advance our understanding of the connotations of different processed products of Bupleuri Radix, standardize the processing technology and formulate better quality standards, provide processed products of Bupleuri Radix that are stable and controllable in quality and of different varieties for clinical use, and give full play to the clinical superiorities of Bupleuri Radix.

Key words: Bupleurum, processing, vinegar bupleurum, turtle blood bupleurum, processing technology, Tong Quan Da Bian

中图分类号:

R932
R994.11

郑长辉, 马丽娜, 何婷, 赵薇, 顾媛媛, 胡晓祯, 牛源菲, 郭跃山, 曹俊岭. 基于“通权达变”思想探究柴胡不同炮制方法[J]. 中国药物警戒, 2024, 21(8): 955-960.

ZHENG Changhui, MA Lina, HE Ting, ZHAO Wei, GU Yuanyuan, HU Xiaozhen, NIU Yuanfei, GUO Yueshan, CAO Junling. Methods of preparation of Bupleuri Radix based on the idea of ‘Tong Quan Da Bian’[J]. Chinese Journal of Pharmacovigilance, 2024, 21(8): 955-960.

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