多成分定量联合GRA及EW-TOPSIS法评价柴胡疏肝颗粒质量

doi:10.19803/j.1672-8629.20230173

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (11): 1243-1248.
DOI: 10.19803/j.1672-8629.20230173

多成分定量联合GRA及EW-TOPSIS法评价柴胡疏肝颗粒质量

刘科成, 魏谭军, 陈飞, 肖成, 张银素^*

达州市中西医结合医院,达州市第二人民医院药学科,四川达州 635000

收稿日期:2023-03-23 出版日期:2023-11-15 发布日期:2023-11-13
通讯作者: 张银素,女,本科,副主任中药师,中药鉴别与调剂。E-mail: deac78@163.com
作者简介:刘科成,男,本科,副主任中药师,中药鉴别与质量评价。
基金资助:
四川省重点研发项目（2020YFS0533）

Quality evaluation of Chaihu Shugan granules ria multi-component quantification combined with GRA and EW-TOPSIS method

LIU Kecheng, WEI Tanjun, CHEN Fei, XIAO Cheng, ZHANG Yinsu^*

Department of Pharmacy, Dazhou Integrated TCM & Western Medical Hospital & Dazhou Second People’s Hospital, Dazhou Sichuan 635000, China

Received:2023-03-23 Online:2023-11-15 Published:2023-11-13

摘要/Abstract

摘要： 目的建立多成分定量联合灰色关联度分析（GRA）及熵权逼近理想解排序（EW-TOPSIS）法评价柴胡疏肝颗粒综合质量的方法。方法以Shimadzu C₁₈为色谱柱,乙腈-0.1%磷酸为流动相,采用一测多评（QAMS）法同时测定柴胡疏肝颗粒中芍药内酯苷、芍药苷、香附烯酮、圆柚酮、α-香附酮、柴胡皂苷a、柴胡皂苷d、柚皮苷、橙皮苷、新橙皮苷、洋川芎内酯A、瑟丹酸内酯和藁本内酯含量;分别构建18批样品GRA和熵权TOPSIS质量评价模型,并对分析结果进行对比。结果柴胡疏肝颗粒中13种成分在各自范围内线性关系良好（r ≥0.999）,平均加样回收率（n=9）在96.91%~100.07%（RSD<2.0%）,QAMS与外标法结果无明显差异（P>0.05）;GRA结果相对关联度为0.321 6~0.604 9,EW-TOPSIS法结果相对接近度为0.244 9~0.664 5,GRA与EW-TOPSIS模型综合评价结果基本一致。结论该方法可用于柴胡疏肝颗粒多指标成分定量控制及质量评价。

关键词: 柴胡疏肝颗粒, 一测多评法, 灰色关联度, 熵权-逼近理想解排序, 质量评价

Abstract: Objective To establish a multi-component quantification combined with GRA and EW-TOPSIS method to evaluate the quality of Chaihu Shugan granules. Methods The determination was performed on a Shimadzu C₁₈ column with the mobile phase composed of acetonitrile-0.1% phosphoric acid. The contents of albiflorin, paeoniflorin, cyperenone, nootkatone, α-cyperone, saikosaponin A, saikosaponin D, naringin, hesperidin, neohesperidin, senkyunolide A, neocnidilide and ligustilide in Chaihu Shugan granules were calculated using the QAMS method. The models for quality evaluation of GRA and EW-TOPSIS in 18 batches of samples were constructed respectively, and the results of analysis were compared. Results The 13 components of Chaihu Shugan granules showed good linear relationships within their respective ranges (r≥0.999), and the average recoveries (n=9) ranged from 96.91% to 100.07%(RSD<2.0%). There was no obvious difference between QAMS and ESM(P>0.05). The relative correlation degree with the GRA method was 0.321 6-0.604 9, and the relative proximity with the EW-TOPSIS analysis method was 0.244 9-0.664 5. The overall results of evaluation by GRA and EW-TOPSIS models were basically the same. Conclusion This method can be used for quantitative control and quality evaluation of multi-components in Chaihu Shugan granules.

Key words: Chaihu Shugan granules, QAMS, GRA, EW-TOPSIS, quality evaluation

中图分类号:

R927
R994.11

刘科成, 魏谭军, 陈飞, 肖成, 张银素. 多成分定量联合GRA及EW-TOPSIS法评价柴胡疏肝颗粒质量[J]. 中国药物警戒, 2023, 20(11): 1243-1248.

LIU Kecheng, WEI Tanjun, CHEN Fei, XIAO Cheng, ZHANG Yinsu. Quality evaluation of Chaihu Shugan granules ria multi-component quantification combined with GRA and EW-TOPSIS method[J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1243-1248.

参考文献

[1] WAN Y, LI C, QIU Q, et al.Multi-component and multi-target synergistic pharmacological efficacy evaluation system of traditional Chinese medicine compound[J]. Science China(中国科学), 2016, 46(8): 1029-1032.
[2] LI L, PAN QW, LIY H.Application of grey relational analysis in the study of spectrum-effect of traditional Chinese medicine[J]. China Pharmacy(中国药房), 2018, 29(11): 1581-1584.
[3] WANG YX, WU XY, XIA PF, et al.Entropy-based TOPSIS model for comprehensive evaluation of quality of differently dried Rosa sertata X. Rosa rugosa[J]. Chinese Traditional Patent Medicine(中成药), 2021, 43(5): 1241-1248.
[4] Sichuan Food and Drug Products Administration. Preparation standards of medical institutions in Dazhou Integrated TCM & Western Medical HospitalDZBZ2022003[S]. Chengdu: Sichuan Food and Drug Products Administration, 2022.
[5] ZHANG JB.Jingyue Encyclopedia·Ancient Eight·ArraysScatter Arrays(景岳全书·古方八阵·散阵)[M]. Shanghai: Shanghai Science and Technology Press, 1959.
[6] Sichuan Food and Drug Products Administration. Technical Guideline for Preparation Research of Medical Institutions in Sichuan Province(Trial Edition)[EB/OL].(2015-04-17)[2015-04-23].http://yjj.sc.gov.cn/scyjj/gztz/2015/4/23/6119b3e87a214a3d939f1dad22a24db8.shtml.
[7] WANG AF, LYU HX.Observation on therapeutic effect of Chaihu Shugan granules on 60 cases of hyperplasia of mammary glands[J]. Medical Diet and Health(医学食疗与健康), 2020, 18(16): 12-13.
[8] FENG JY, LUO XY, YANG SR, et al.Observation on curative effect of chaihu shugan granules combined with femoston in treatment of perimenopausal syndrome[J]. Journal of Practical Traditional Chinese Medicine(实用中医药杂志), 2022, 38(5): 745-746.
[9] YUE XY.Clinical study on Chaihu Shugan powder combined with Wenxin Granules in treatment of hypertension with anxiety of liver-qi stagnation type[J]. Inner Mongolia Journal of Traditional Chinese Medicine(内蒙古中医药), 2018, 37(11): 3-4.
[10] MA M, LEI MZ.Determination of oxypaeoniflora, albiflorin, paeoniflorin, liquiritin, isoliquiritin, cinnamic acid, cinnamaldehyde, glycyrrhizic acid in Xiaojianzhong tablets by HPLC-CAD[J]. Drugs & Clinic(现代药物与临床), 2022, 37(3): 503-507.
[11] QIAO JH, LI YY, GU MD.Simultaneous determination of five constituents in Yinban Prescription by HPLC wavelength switching method[J]. Shanghai Journal of Traditional Chinese Medicine(上海中医药杂志), 2021, 55(8): 75-79.
[12] YAO Y, CHEN YY, HUANG YH.Determination of paeoniflorin and alibiflorin in ShenQi YiMu Ointment by HPLC[J]. Strait Pharmaceutical Journal(海峡药学), 2021, 33(7): 56-58.
[13] YANG Y, LIU YH, HUANG ZF, et al.Determination of senkyunolide A and ligustilide in Chuanxiong Rhizoma and Angelicae Sinensis Radix by QAMS[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2015, 21(3): 58-62.
[14] YANG W, ZHANG YZ, YANG BX.Determination of polydatin, resveratrol, oxypaeoniflorin, paeoniflorin, saikosaponin A, saikosaponin B₁, and saikosaponin D in Ganshuang Granules by HPLC-QAMS[J]. Drugs & Clinic(现代药物与临床), 2022, 37(2): 285-290.
[15] LIU M, YIN Q, ZHAO L, et al.Simultaneous determination of nine active ingredients in Zhengchaihuyin granules by HPLC-DAD[J]. Food and Drug(食品与药品), 2021, 23(5): 458-464.
[16] SONG Q, ZHENG H, HUANG JY.Simultaneous determination of naringin, hesperidine, neohesperidin and baicalin in Hewei Xiaopi pills by HPLC[J]. Food and Drug(食品与药品), 2021, 23(5): 425-428.
[17] JIAO YY, TIAN GL.Determination of eight components in Toufengtong pills by HPLC and comprehensive evaluation of chemometrics[J]. Drugs & Clinic(现代药物与临床), 2021, 36(9): 1807-1811.
[18] YAN YJ, CUI T, DING Q, et al.Comprehensive quality evaluation of Lysimachia christinae based on the entropy weight TOPSIS method combined with multiple indicator components[J]. China Pharmacy(中国药房), 2020, 31(23): 2870-2876.
[19] ZOU JL, WANG KY, HE WY, et al.Research on the classification of angelica sinensis real estate areas based on entropy weight method and grey correlation analysis[J]. Journal of Chinese Medicinal Materials(中药材), 2022, 45(5): 1173-1178.

多成分定量联合GRA及EW-TOPSIS法评价柴胡疏肝颗粒质量

Quality evaluation of Chaihu Shugan granules ria multi-component quantification combined with GRA and EW-TOPSIS method

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