中国药物警戒 ›› 2024, Vol. 21 ›› Issue (5): 594-600.
DOI: 10.19803/j.1672-8629.20230758

• 综述 • 上一篇    

基于七情配伍理论的补骨脂药对配伍规律研究进展

王晓艳1,2,3,4, 陈小菲1,2,3,4, 张辉1,2,3,4, 张明亮1,2,3,4, 吴娅丽1,2,3,4, 杨柳青1,2,3,4, 唐进法1,2,3,4,*, 李伟霞1,2,3,4#   

  1. 1河南中医药大学第一附属医院药学部,河南 郑州 450000;
    2河南省中药临床应用、评价与转化工程研究中心,河南 郑州 450000;
    3河南省中药临床药学中医药重点实验室,河南 郑州 450000;
    4河南省中药安全评价与风险防控工程研究中心,河南 郑州 450000
  • 收稿日期:2023-12-01 出版日期:2024-05-15 发布日期:2024-05-13
  • 通讯作者: *唐进法,男,博士,主任药师·博导,中药质量评价与合理用药。E-mail: a0519@163.com #为共同通信作者。
  • 作者简介:王晓艳,女,博士,副主任药师·硕导,中药药理与毒理。
  • 基金资助:
    国家自然科学基金资助项目（82173993、U1904129）; 河南省自然科学基金资助项目（212300410188）; 河南省中医药科学研究专项课题（2019ZYBJ08）; 河南省高校科技创新团队（23IRTSTHN026）; 河南省中医药拔尖人才培养项目（豫中医科教[2018]35号）

Research progress in drug-pair compatibility principles of Psoraleae Fructus based on theories of seven features of compatibility

WANG Xiaoyan1,2,3,4, CHEN Xiaofei1,2,3,4, ZHANG Hui1,2,3,4, ZHANG Mingliang1,2,3,4, WU Yali1,2,3,4, YANG Liuqing1,2,3,4, TANG Jinfa1,2,3,4,*, LI Weixia1,2,3,4#   

  1. 1Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou Henan 450000, China;
    2Henan Province Engineering Research Center for Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine, Zhengzhou Henan 450000, China;
    3Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine, Zhengzhou Henan 450000, China;
    4Henan Province Engineering Research Center of Safety Evaluation and Risk Management of Traditional Chinese Medicine, Zhengzhou Henan 450000, China
  • Received:2023-12-01 Online:2024-05-15 Published:2024-05-13

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摘要： 目的 基于中药七情配伍理论归纳补骨脂药对配伍规律,为补骨脂临床合理应用提供依据。方法 通过古籍与现代文献检索与分析,从相须相使、协同增效、相畏相杀、减毒降副,配伍禁忌三方面总结补骨脂配伍规律。结果 基于七情配伍理论探析补骨脂药对的配伍规律,补骨脂常用相须相使药对为肉豆蔻、蛇床子、小茴香、益智仁、肉桂、吴茱萸、巴戟天、杜仲、骨碎补、仙茅,常用相畏相杀药对为胡桃仁、生地黄、五味子、赤芍,相恶、相反禁忌药对有甘草、淫羊藿。结论 总结了常与补骨脂配伍的药对,为临床遣方用药提供思路。

关键词: 中药七情, 配伍, 药对, 补骨脂, 增效, 减毒, 整体观念

Abstract: Objective To summarize the research progress related to Psoraleae Fructus drug pairs based on the theory of seven features of compatibility, and provide data for rational clinical applications of Psoraleae Fructus. Methods Through literature research and analysis, the research progress concerning Psoraleae Fructus drug pairs was summarized in terms of mutual reinforcement/assistnce, synergistic effect enhancement, mutual restraint/suppression, reduction of toxicity and side effects, and compatibility contraindications. Results Based on theories of seven features of compatibility and on studies of clinical medication principle of Psoraleae Fructus drug pairs, it was found that the mutually-reinforcing and mutually-assisting herb pairs of Psoraleae Fructus included Myristicae Semen, Cnidh Fructus, Foeniculi Fructus, Alpiniae Oxyphyllae Fructus, Cinnamomi Cortex, Euodiae Fructus, Morindae Officinalis Radix, Eucommiae Cortex, Drynariae Rhizoma and Curculiginis Rhizoma while the mutually-restricting and mutually-suppressing herb pairs included Juglandis Semen, Rehmanniae Radix, Schisandrae Chinensis Fructus, Paeoniae Radix Rubra. The mutually-inhibiting and mutually-antagonizing herb pairs included Glycyrrhizae Radix Et Rhizoma and Epimedii Folium. Conclusion This article summarizes the drug pairs that are often compatible with Psoraleae Fructus, providing ideas for clinical prescriptions.

Key words: seven emotions of Chinese materia medica, compatibility, drug pairs, Psoraleae Fructus, increasing efficiency, detoxification, overall concept

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