海藻-甘草配伍毒效关系可视化分析

doi:10.19803/j.1672-8629.20240380

摘要/Abstract

摘要： 目的梳理海藻-甘草配伍应用的研究热点和趋势,归纳其药效和毒性机制以及毒效关系,为临床安全高效应用海藻-甘草提供参考。方法应用文献计量学和数据挖掘方法,对海藻-甘草配伍应用相关的动物实验和临床研究进行可视化分析。结果共纳入研究文献184篇。对关键词进行归纳,以有效性与安全性为该领域主要研究方向,以甲状腺肿、细胞增殖、肝毒性、肝药酶等为机制研究热点;对动物实验文献进行毒效关联分析,两者毒效关系与配伍比例、剂量、给药方法、药物组合等密切相关,在发挥纠正甲状腺系数、抗甲状腺肿、保肝作用的同时会引起诱导肝药酶、影响心肌酶、减少药物排泄等不良反应,随着海藻剂量升高不良反应增多。结论海藻-甘草配伍应用的药效与毒性在一定条件下同时存在、相互转化,以中医整体观念与理论指导为核心依托、以毒效关系为关键抓手,整合海藻-甘草在理论探讨、实验研究、临床用药的丰富经验,为临床应用提供参考。

关键词: 海藻, 甘草, 配伍, 毒效关系, 文献计量分析, 数据挖掘

Abstract: Objective To find out about the hot spots in research on applications of herbal pair-Sargassum (Haizao, HZ) and Glycyrrhizae Radix et Rhizoma (Gancao, GC)-and to explore the pharmacological and toxic mechanisms and the toxicity/efficacy relationship in order to facilitate safe and effective clinical use. Methods Bibliometrics and data mining were used for visual analysis of animal and clinical studies related to herbal pair HZ-GC. Results A total of 184 articles were included. The keywords were summarized and the related research was divided into two big categories: effectiveness and safety. The hot spots related to mechanisms included goiter, cell proliferation, hepatotoxicity and liver drug enzymes. A toxicity-effect correlation analysis conducted on animal experimental literature showed that the toxicity/efficacy relationship of this herbal pair was closely related to the proportion, dosage, administration methods and applications in the compound formula. Despite its role in correcting thyroid indexes, anti thyroid swelling and protecting the liver, the herbal pair caused such adverse reactions as inducing liver enzymes, affecting myocardial enzymes and reducing drug excretion. The adverse reactions increased along with the dosage of Sargassum. Conclusion The herbal pair HZ-GC has both therapeutic effects and adverse reactions that may coexist and transform into each other under certain conditions. Based on the holistic perspective and guidance of TCM and by focusing on the toxicity/efficacy relationship, the integration of theoretical studies, experimental research and clinical medications is of great significance for its clinical applications.

Key words: Sargassum, Glycyrrhizae Radix et Rhizoma, Compatibility, Toxicity/Efficacy Relationship, Bibliometric Analysis, Data Mining

中图分类号:

R994.11

陈霙仁, 薛泽宇, 黄天驰, 梁懿洪, 林子淇, 修琳琳. 海藻-甘草配伍毒效关系可视化分析[J]. 中国药物警戒, 2025, 22(1): 93-98.

CHEN Yingren, XUE Zeyu, HUANG Tianchi, LIANG Yihong, LIN Ziqi, XIU Linlin. Toxicity/Efficacy Relationship of Sargassum and Glycyrrhizae Radix et Rhizoma: a Visual Analysis[J]. Chinese Journal of Pharmacovigilance, 2025, 22(1): 93-98.

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https://zgywjj.magtechjournal.com/CN/Y2025/V22/I1/93

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