中国药物警戒 ›› 2024, Vol. 21 ›› Issue (8): 943-945.
DOI: 10.19803/j.1672-8629.20240158

• 安全与合理用药 • 上一篇    下一篇

注射用头孢曲松钠致儿童输尿管结石及胆囊结石1例分析

晁滢1, 张学梅2, 张成健2, 王贝1,*   

  1. 1东南大学医学院附属南京同仁医院药学部,江苏 南京 211102;
    2东南大学医学院附属南京同仁医院儿科,江苏 南京 211102
  • 收稿日期:2024-03-07 出版日期:2024-08-15 发布日期:2024-08-21
  • 通讯作者: *王贝,女,本科,主管药师,临床药学。E-mail: 15852931422@163.com
  • 作者简介:晁滢,女,硕士,药师,药理学。

One case of ureterolith combined with gallstone caused by Ceftriaxone sodium for injection in children

CHAO Ying1, ZHANG Xuemei2, ZHANG Chengjian2, WANG Bei1,*   

  1. 1Department of pharmacy, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing Jiangsu 211102, China;
    2Department of pediatrics, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing Jiangsu 211102, China
  • Received:2024-03-07 Online:2024-08-15 Published:2024-08-21

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摘要： 目的 探讨注射用头孢曲松钠致儿童输尿管结石及胆囊结石的机制,为临床安全合理使用注射用头孢曲松钠提供参考。方法 分析患儿接受头孢曲松钠治疗后发生输尿管结石及胆囊结石的诊疗过程,检索同类文献报道,分析其药品不良反应发生机制和临床应对策略。结果 患儿使用注射用头孢曲松钠5 d后出现输尿管结石及胆囊结石,停用注射用头孢曲松钠后,输尿管结石自然好转。结合相关文献分析,儿童使用注射用头孢曲松钠后,可能出现输尿管结石及胆囊结石,但大多数停药后可自动消失。结论 注射用头孢曲松钠很可能导致患儿输尿管结石及胆囊结石,儿科临床治疗过程中应该予以重视。

关键词: 注射用头孢曲松钠, 输尿管结石, 胆囊结石, 药品不良反应, 儿童

Abstract: Objective To explore the mechanism of ceftriaxone injection causing ureterolith and gallstone in children, and provide reference for the safe and reasonable use of ceftriaxone injection in clinical practice. Methods The diagnosis and treatment process of ureterolith and gallstone in the children after receiving treatment with ceftriaxone was analyzed. And Related literature were searched to analyze the mechanism of adverse drug reactions and clinical countermeasures. Results After 5 days of using ceftriaxone, this child developed ureterolith and gallstones. After discontinuing the use of ceftriaxone, ureterolith naturally improved. Based on the analysis of relevant literature, children may develop ureterolith and gallstone after using ceftriaxone, but most of them disappear automatically after discontinuation. Conclusion Ceftriaxone is likely to cause ureterolith and gallstone in children, which deserves more attention in clinic.

Key words: Ceftriaxone, ureterolith, gallstone, adverse drug reaction, children

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