中国药物警戒 ›› 2024, Vol. 21 ›› Issue (7): 765-770.
DOI: 10.19803/j.1672-8629.20240345

• 药源性心脏毒性研究专栏 • 上一篇    下一篇

药源性心脏毒性模型的构建与评价进展

蔡海丽1, 张晓朦1,2, 刘亚迪1, 刘淑佳1, 高福君1, 王雨1,2, 张冰1,2,*   

  1. 1北京中医药大学中药学院,北京 102488;
    2北京中医药大学中药药物警戒与合理用药研究中心,北京 102488
  • 收稿日期:2024-05-22 出版日期:2024-07-15 发布日期:2024-07-31
  • 通讯作者: * 张冰,女,博士,教授·博导,主任医师,中药药物警戒与合理用药。E-mail: zhangb@bucm.edu.cn
  • 作者简介:蔡海丽,女,硕士,中药药物警戒与合理用药。
  • 基金资助:
    国家自然科学基金资助项目(82274117); 国家自然科学基金青年科学基金资助项目（82204643）; 国家中医药管理局高水平重点学科建设项目-临床中药学（zyyzdxk-2023257）; 中央高校基本科研业务费专项资金(2024-JYB-JBZD-054)

Progress in construction and evaluation of a drug-induced cardiotoxicity model

CAI Haili1, ZHANG Xiaomeng1,2, LIU Yadi1, LIU Shujia1, GAO Fujun1, WANG Yu1,2, ZHANG Bing1,2,*   

  1. 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    2Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
  • Received:2024-05-22 Online:2024-07-15 Published:2024-07-31

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摘要： 目的 了解药源性心脏毒性动物模型的建立与应用,为药源性心脏毒性的防治提供研究基础。方法 采用文献研究,以“心脏毒性”和“cardiotoxicity”等为主题词,在中国知网和Web of science core collection数据库选取2015年1月1日至2024年4月4日应用药源性心脏毒性模型的相关文献,按照纳入标准筛选出应用药源性心脏毒性动物模型的实验研究文献,并使用分析软件Citespace 6.3R1（64-bit）Basic结合Excel对纳入文献进行可视化呈现。结果 共纳入731篇文献。应用于药源性心脏毒性研究的模式动物多选用大鼠、小鼠、斑马鱼,造模剂以阿霉素、乌头碱、布比卡因为主,毒性机制涉及氧化应激、细胞凋亡等。大多采用一般指标、组织病理指标、心脏功能检测指标等多类别指标变化进行综合评价。其应用也较为集中,评价药源性心脏毒性模型的标准存在较大差异。结论 目前药源性心脏毒性模型的研究仍具有一定的发展前景,为系统开展中医药防治药源性心脏毒性提供依据。

关键词: 药源性, 心脏毒性, 动物模型, 评价指标, 药物警戒, 大鼠, 小鼠, 斑马鱼

Abstract: Objective To find out about the establishment and applications of animal models for drug-induced cardiotoxicity, and to provide data for the prevention and treatment of drug-induced cardiotoxicity. Methods Literature research was conducted using “cardiotoxicity” as the key term. Related literature on applications of drug-induced cardiotoxicity models published since 2015 was selected from the CNKI and Web of Science Core Collection databases. Literature about experimental research on applications of animal models for drug-induced cardiotoxicity was screened based on the inclusion criteria. Analysis software Citespace 6.3 R1 (64-bit) Basic as well as Excel was used to visualize the selected literature. Results A total of 731 articles were included. The model animals used in studies of drug-induced cardiotoxicity were mostly rats, mice and zebrafish while the modeling agents were chiefly adriamycin, aconitine and bupivacaine. The toxicity mechanism involved oxidative stress and apoptosis. Most studies used such multi-category indicators as general indicators, histopathological indicators, and cardiac function test indicators for comprehensive evaluation. The applications were also relatively concentrated, and there were great differences in the criteria for evaluating drug-induced cardiotoxicity models. Conclusion Research on drug-induced cardiotoxicity models remains promising, which can facilitate systematic development of Traditional Chinese Medicine for the prevention and treatment of drug-induced cardiotoxicity.

Key words: drug-induced, cardiotoxicity, animal model, evaluation indicators, pharmacovigilance, rat, mice, zebrafish

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