中国药物警戒 ›› 2016, Vol. 13 ›› Issue (2): 107-110.

• 安全性评价与合理用药 • 上一篇    下一篇

66例醒脑静注射液不良反应的文献分析

刘宏明1, 许莉莉2, 崔冉1, 翟淑越1   

  1. 1淄博市药品不良反应监测中心,山东 淄博 255000;
    2.山东省药品不良反应监测中心,山东 济南 250013
  • 收稿日期:2016-03-14 修回日期:2016-03-14 出版日期:2016-02-08 发布日期:2016-03-14
  • 作者简介:刘宏明,男,硕士,主管中药师,药品不良反应监测及药品检验分析。

Literature Analysis of 66 Cases of Adverse Drug Reactions Induced by Xingnaojing

LIU Hong-ming1, XU Li-li2, CUI Ran1, ZHAI Shu-yu1   

  1. 1Zibo Municipal Center for ADR Monitoring, Shandong Zibo 255086, China;
    2. Shandong Provincial Center for ADR Monitoring, Shandong Jinan 250013, China
  • Received:2016-03-14 Revised:2016-03-14 Online:2016-02-08 Published:2016-03-14

摘要: 目的通过研究醒脑静注射液不良反应的规律和特点,探讨醒脑静注射液发生不良反应的影响因素,对临床应用提出合理化的建议。方法通过检索文献,对醒脑静注射液不良反应人口学特征、溶媒使用情况、原患疾病、不良反应发生时间、不良反应表现、转归情况进行分析。结果文献中醒脑静注射液引发的不良反应具有发病迅速、损害系统多的特点,临床上存在超适应证用药和药品说明书中缺少儿童用法用量的情况。结论临床上医生应严格按照药品说明书规定的功能主治使用,禁止超功能主治用药。厂家未完善说明书中的儿童用法用量前,应限制使用于儿童。在临床使用中应尽量使用一次性精密输液器,同时应加强监护和控制滴速。

关键词: 醒脑静注射液, 不良反应, 文献分析

Abstract: ObjectiveTo investigate the rules and characteristics of ADRs, explore the influence factors of adverse drug reactions (ADRs) induced by Xingnaojing injection, and put forward reasonable suggestions for clinical application. MethodsDemographic characteristics, solvent, primary disease of patients, occurrence time and appearance of adverse reactions, and outcomes were analyzed by retrieving literature. ResultsXingnaojing injection was characterized, as suggested in literature, by speedy development, multi system damage, and presented problems such as exceeding indications, lacking usage and dosage for children in dispensatory. ConclusionIn clinic, this drug should be used strictly according to the indications for doctors and forbidden exceeding indications. For pharmaceutical enterprise, this drug should not be used for children until its usage and dosage for children was added in directions. The disposable precise infusion apparatus should be used in clinical as far as possible. Simultaneously, intensive care and controlling dropping speed should be practiced.

Key words: Xingnaojing injection, adverse drug reaction, literature analysis

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