中国药物警戒 ›› 2014, Vol. 11 ›› Issue (1): 23-26.

• 药械安全性研究 • 上一篇    下一篇

基于累及器官和发生频率的有毒中药不良反应统计分析

王懿1,2,孙蓉2*,*   

  1. 1山东中医药大学,山东 济南 250355;
    2山东省中医药研究院,山东 济南 250014
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-01-08 发布日期:2016-02-03
  • 通讯作者: 孙蓉,女,研究员·博导,博士,中药药理与毒理。
  • 作者简介:王懿,女,在读硕士,中药药理与毒理。

Statistical Analysis on the Adverse Reaction of Toxic Chinese Medicine Based on the Affected Organs and the Frequency of Occurrence

WANG Yi1, 2, SUN Rong2, *   

  1. 1Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China;
    2Shandong Research Academy of TCM, Shandong Jinan 250014, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-01-08 Published:2016-02-03

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摘要： 目的分析有毒中药不良反应的累及器官和发生频率,为临床不良反应有效监测提供文献数据支持。方法按中药类别对药典记载的83味有毒中药临床不良反应报道进行整理、分析与归纳。结果各类有毒中药不良反应累及系统为神经系统、循环系统、血液系统、消化系统、呼吸系统、泌尿系统、生殖系统、皮肤及附件,依发生频率高低分析可见,神经系统最常见,占总发生率的23.6%,消化系统占23.3%,依次递减还累及循环系统、呼吸系统、泌尿系统、生殖系统、皮肤等。结论有毒中药不良反应主要发生在神经系统和消化系统,其次为循环、呼吸、等系统;明晰有毒中药不良反应的常见累及器官和发生频率,对于临床合理使用上述药物以及有效防控其不良反应具有重要的意义。

关键词: 累及器官, 发生频率, 有毒中药, 不良反应, 统计分析

Abstract: ObjectiveTo provide literature data for clinical monitoring of adverse drug reactions based on analyzing the affected organs and the frequency of adverse reaction of toxic Chinese medicine. MethodsReports about adverse reaction of 83 toxic Chinese medicines recorded in pharmacopeia according to traditional Chinese medicine(TCM) category were collated, analyzed and summarized. ResultsThe adverse reaction of toxic Chinese medicine involved nervous system, circulatory system, blood system, digestive system, respiratory system, urinary system, reproductive system, skin and accessories. For analysing the frequency of adverse reaction of toxic Chinese medicine, the most common adverse reaction was nervous system and the percentage was 23.6, the second one was digestive system and the percentage was 23.3, decreasing order was circulatory system, respiratory system, urinary system, reproductive system. skin and accessories. ConclusionNervous system and digestive system were the primary systems, the adverse reaction of toxic Chinese medicine also appeared at circulatory system, respiratory system and so on. Make clear the affected organs and the frequency of adverse reaction of toxic Chinese medicine, which has great significance for clinical rational use of these drugs and effective prevention and control of the adverse reactions.

Key words: affected organs, frequency of occurrence, toxic Chinese medicine, adverse drug reaction, statistical analysis

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