中国药物警戒 ›› 2014, Vol. 11 ›› Issue (1): 27-30.

• 药械安全性研究 • 上一篇    下一篇

基于盐酸克林霉素注射剂不良反应监测数据探索聚类分析方法在药品不良反应监测中的应用

路长飞,田月洁*   

  1. 山东省药品不良反应监测中心,山东 济南250013
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-01-08 发布日期:2016-02-03
  • 通讯作者: 田月洁,男,副主任药师,药品不良反应监测与评价。
  • 作者简介:路长飞,男,药师,药品不良反应监测与评价。

Exploration on Use of Cluster Analysis Method in Adverse Drug Reaction Monitoring：Based on Clindamycin Hydrochloride Injection Adverse Reaction Monitoring Data

LU Chang-Fei, TIAN Yue-Jie*   

  1. Shandong Center for ADR Monitoring, Shandong Jinan 250013, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-01-08 Published:2016-02-03

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摘要： 目的探索聚类分析方法在药品不良反应监测数据中的运用。方法选取9家生产企业（编码为A~I）生产的盐酸克林霉素注射剂不良反应/事件的监测数据,根据其不良反应信息采用聚类分析法将企业进行分组,以此发现不同生产企业产品致不良反应的特点。结果9家企业按照药品不良反应累及系统-器官归类为4组,且组间差异较大;各组企业药品致不良反应具有不同的特点。结论不同企业的生产工艺可能导致同种药品致不良反应的不同;聚类分析可以在药品不良反应监测中运用。

关键词: 药品不良反应, 监测, 聚类分析, 探索

Abstract: ObjectiveTo explore the use of cluster analysis method in adverse drug reaction monitoring. MethodsIn order to define the characteristics of different manufacturers, the manufacturers were grouped by the cluster analysis method based on the clindamycin hydrochloride injection adverse reaction monitoring data which were in the charge of 9 manufacturers(coded as A to I). ResultsThe 9 manufacturers were classified as 4 groups according to the system-organ that adverse drug reactions attacked. There was great difference between the groups. The adverse reactions of certain drug had different characteristics in different group of manufacturers. ConclusionDifferent manufacturers' production process may lead to different adverse drug reactions. Cluster analysis method can be used in the adverse drug reaction monitoring.

Key words: adverse drug reaction, monitoring, cluster analysis, exploration

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