中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 543-544.

• 药品质量与工艺研究 • 上一篇    下一篇

RP-HPLC测定保精颗粒中五味子醇甲的含量

唐晓霞,陈丽,苏万福   

  1. 济川药业集团股份有限公司,江苏泰兴 225441
  • 收稿日期:2013-05-27 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 作者简介:唐晓霞,女,工程师,中药分析。

A Method for Quantitative Determination of Schisandrim in Baojing Granule by RP-HPLC

TANG Xiao-xia, CHEN Li ,SU Wan-fu   

  1. Jumpcan Pharmaceutical Group Limited by Share, Jiangsu Taixing 225441, China
  • Received:2013-05-27 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 建立保精颗粒中五味子醇甲的含量测定方法。方法 采用高效液相色谱法,Kromasil C18（250 mm×4.6 mm,5μm）色谱柱,流动相为乙腈- 水（45:55）,流速1.0 mL·min-1,检测波长250 nm。结果 方法学考察结果表明,五味子醇甲平均加样回收率为100.7%（RSD=1.3%,n=6）。结论 该方法专属性强、重复性好,可作为保精颗粒的质量控制方法。

关键词: 保精颗粒, 五味子醇甲, RP-HPLC, 含量测定

Abstract: Objective To establish a method for quantitative determination of schisandrin in baojing granule. Methods HPLC was used. The samples were separated ona kromasil C18 column(250mm伊4.6mm,5μm) witha mobile phase of acetonitrile and water( 45:55,v/v) , pumped at the flow rate of 1.0 mL·min -1 and detected at 250 nm. Results The result showed that the average recovery of schisandrin was 100.7% (RSD=1.3% , n=6). Conclusion The method hasa good specificity and stability, which can be applied to the quality control of baojing granule.

Key words: baojing granule, schisandrin, RP-HPLC, assaying

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