中国药物警戒 ›› 2013, Vol. 10 ›› Issue (4): 238-240.

• 药械安全性研究 • 上一篇    下一篇

65例-内酰胺类药物致心血管不良反应的文献分析

张婧,王金华,刘璐,李丹露,李希娜   

  1. 哈尔滨医科大学附属第一医院药学部,黑龙江哈尔滨 150001
  • 收稿日期:2012-08-08 修回日期:2016-03-09 出版日期:2013-04-08 发布日期:2016-03-09
  • 作者简介:张婧,女,药师,医院药学与临床药学。

Literature Analysis of 65 Cases of ADR in Cardiovascular System Induced by β-Lactam Antibiotics

ZHANG Jing ,WANG Jin –Hua, LIU Lu ,LI Dan -Lu ,LI Xi –Na   

  1. Department of Pharmacy, the First Hospital of Harbin Medical University, Heilongjiang Harbin 150001, China
  • Received:2012-08-08 Revised:2016-03-09 Online:2013-04-08 Published:2016-03-09

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摘要： 目的 通过对β-内酰胺类药物致心血管不良反应的文献进行分析,探讨其引起心血管系统不良反应的规律,为临床合理应用β-内酰胺类药物提供参考。方法 以“ β- 内酰胺类”、“青霉素”、“头孢”、“不良反应”等关键词对1987 年～2012年中国知网（CNKI）数据库文献进行检索,对其中涉及β-内酰胺类药物致心血管不良反应的43 篇文献中报道的65 例病例报告进行统计与分析。结果 引起心血管不良反应的β- 内酰胺类药物共涉及16个品种,其中报道最多的是青霉素,其次为头孢唑林和头孢拉定；心血管不良反应的表现以心律失常为最多（73.85%）；其次为急性心力衰竭（23.08%）；不良反应多呈速发型,尤其多发于用药10min 以内（53.85%）。结论 应重视β-内酰胺类药物的心血管不良反应,在应用过程中注意观察,做到及早发现、正确处理。

关键词: 药品不良反应, β-内酰胺类, 心血管系统

Abstract: Objective To study the features of adverse drug reaction(ADR) in cardiovascular system induced by -lactam antibiotics through literature analysis and provide reference for clinical rational use of β-lactam antibiotics. Methods To collect literatures from 1987 to 2012 reported in China National Knowledge Infrastructure (CNKI) with" β-lactam antibiotics"、"penicillin"、" cef -/ceph -" "ADR" as key words, and to analyze statistically the 65 ADR cases, involved in 43 articles of β-lactam antibiotics in cardiovascular system. Results Totally there were 16 varieties involved. Penicillin was most frequently reported. Cefazolin and cefradine were the second. Arrhythmia was the most common manifestation of cardiac toxicity(73.85% ), followed by acute heart failure (23.08% ). Most ADR appeared as fast -type, especially occurred during the first 10 minutes (53.85% ). Conclusion We should pay more attention to the ADR of β-lactam antibiotics in cardiovascular system. It needs to observe closely during application, in order to detect earlier and deal correctly.

Key words: adverse drug reaction(ADR), β-lactam, cardiovascular system

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