中国药物警戒 ›› 2026, Vol. 23 ›› Issue (10): 1092-1097.
DOI: 10.19803/j.1672-8629.20260237

• 中枢神经系统罕见肿瘤药物研究专栏 • 上一篇    下一篇

新型脊索瘤诊断药物在小鼠体内的毒性作用研究

刘一德1, 曲爽2, 张敏1, 白吉伟1, 俞丙然2, 刘潜1*   

  1. 1首都医科大学北京市神经外科研究所,北京 100070;
    2北京化工大学材料科学与工程学院,北京 100029
  • 收稿日期:2026-03-23 出版日期:2026-10-15 发布日期:2026-10-16
  • 通讯作者: *刘潜,女,博士,副研究员,药理学。E-mail: liuqian1313@163.com
  • 作者简介:刘一德,男,硕士,神经外科学。
  • 基金资助:
    国家自然科学基金资助项目（82272939、H2706）;北京天坛医院创新转化大赛资助（TYZH2026016）

Toxic effects of a novel chordoma diagnostic agent in mice

Liu Yide1, Qu Shuang2, Zhang Min1, Bai Jiwei1, Yu Bingran2, Liu Qian1*   

  1. 1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China;
    2College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2026-03-23 Online:2026-10-15 Published:2026-10-16

PDF (PC)

29

摘要： 目的 探究一种新型脊索瘤诊断药物在动物体内的毒性作用,为探索新脊索瘤临床诊治方法提供参考。方法 雌雄C57小鼠共48只,分4组,以尾静脉注射的方式,分别给予高浓度（2.0 mg·kg-1）、应用浓度（0.4 mg·kg-1）、低浓度（0.08 mg·kg-1）的新型诊断药物。给药后连续观察14 d,每日监测小鼠存活数量、体重变化、行为活动异常状况等,周期结束后记录小鼠体重曲线及死亡数。观察期结束后将小鼠以规范方式处死,取肝脏、肾脏、心脏、肺、脾等重要器官做石蜡切片并进行苏木精-伊红（HE）染色,观察有无病变。结果 在14 d实验期间内,所有浓度组小鼠均未出现死亡及行为异常等,可知在本研究浓度及时间条件下,该新型诊断药物对小鼠无明显毒性作用。对比给药组及对照组小鼠体重,其增长曲线变化幅度无统计学差异（P<0.05）。结果显示各组小鼠均未出现任何明显的特征性病理变化。结论 该新型诊断药物在本研究设定的剂量和观察期内无明显急性毒性表现。

关键词: 中枢神经系统疾病, 脊索瘤, 诊断药物, 体内毒性, 小鼠

Abstract: Objective To assess the in vivo toxicity of a novel chordoma diagnostic agent in animal models in order to provide data for subsequent investigation into novel diagnostic and treatment strategies for chordoma. Methods Forty-eight male and female C57 mice were randomly assigned to four groups: a high-dose (2 mg·kg-1) group, therapeutic-dose (0.4 mg·kg-1) group, and low-dose (0.08 mg·kg-1) group before being administered with a novel diagnostic agent via tail-vein injection or local infusion through a skin incision. These mice were observed daily for 14 consecutive days while their survival, body-weight changes, and abnormal behavior were recorded. At the end of observation, these mice were sacrificed according to approved protocols before their liver, kidney, heart, lung, spleen, and other key organs were harvested for paraffin sections, HE staining and pathological changes. Results During the 14-day experiment, no mortality or abnormal behavior was observed in mice in any group, suggesting that the novel diagnostic agent as used here had no obvious toxic effects on mice. A comparison of body weight between the treatment groups and the control group found no statistically significant differences in the pattern of weight gain curves (P<0.05). Paraffin-embedded tissue sections showed no characteristic pathological changes in any of the groups. Conclusion The novel diagnostic agent induces no pronounced acute manifestations within the dose range and period established in this study.

Key words: Central Nervous System Disease, Chordoma, Diagnostic Agent, In vivo Toxicity, Mice

中图分类号: